Effects of hypoxemia on regional blood flows during anesthesia with halothane, enflurane, or isoflurane.
Effects of hypoxemia on regional blood flows during anesthesia with halothane, enflurane, or isoflurane.
复制标题
氟烷、安氟烷或异氟烷麻醉期间低氧血症对局部血流的影响。
DOI：
10.1097/00000542-199203000-00013
复制
发表时间：
1992
期刊：
影响因子：
8.8
通讯作者：
Longnecker,DE
中科院分区：
文献类型：
--
作者：
Durieux,ME;Sperry,RJ;Longnecker,DE
麻醉期间的低氧血症可导致严重的发病率和死亡率。为了确定挥发性麻醉剂如何改变低氧血症的正常血流动力学补偿，我们研究了大鼠正常氧血症和正常二氧化碳血症（FIO2 0.12，20 分钟）期间各种麻醉剂对局部血流的影响。使用放射性微球方法，测定用 1 MAC 氟烷、安氟烷或异氟烷麻醉的动物和清醒动物的器官血流量。清醒动物的低氧血症脑血流量显着增加。然而，所有低氧血症麻醉动物的脑血流量均减少。清醒动物的低氧血症时，冠状动脉血流量也显着增加。在存在挥发性麻醉剂的情况下，冠状动脉血流量减少，这种减少在低氧血症时没有变化。因此，清醒低氧动物和麻醉低氧动物之间的大脑和冠状动脉血流量存在很大差异。低氧血症不会改变清醒动物的肾脏、胃肠道或肝脏总血流量。然而，在麻醉的低氧血症动物中，所有三种血流量均显着减少。我们的结论是，挥发性麻醉剂改变了清醒动物对低氧血症的代偿反应，导致流向重要器官的血流减少。
Hypoxemia during anesthesia can cause severe morbidity and mortality. To determine how the volatile anesthetics alter the normal hemodynamic compensation for hypoxemia, we investigated the effects of various anesthetics on regional blood flows during normoxemia and during normocapnic hypoxemia (FIO2 0.12 for 20 min) in rats. Using the radioactive microsphere method, organ blood flows were determined in animals anesthetized with 1 MAC of halothane, enflurane, or isoflurane and in awake animals. Brain blood flow increased significantly with hypoxemia in awake animals. However, brain blood flow decreased in all anesthetized animals that were hypoxemic. Coronary blood flow also increased significantly with hypoxemia in awake animals. In the presence of volatile anesthetics, coronary blood flow decreased, a decrease that was unchanged with hypoxemia. Thus, there was a large difference in brain and coronary blood flows between awake hypoxemic and anesthetized hypoxemic animals. Hypoxemia did not alter the magnitude of renal, gastrointestinal tract, or total hepatic blood flows in awake animals. However, all three blood flows decreased significantly in anesthetized hypoxemic animals. We conclude that volatile anesthetics modify the compensatory responses to hypoxemia that occur in awake animals, resulting in decreased blood flow to vital organs.