COMPUTER AIDS TO PROTEIN SEQUENCE DETERMINATION
COMPUTER AIDS TO PROTEIN SEQUENCE DETERMINATION
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DOI：
10.1016/0022-5193(65)90096-2
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发表时间：
1965-01-01
影响因子：
2
通讯作者：
DAYHOFF, MO
中科院分区：
文献类型：
--
作者：
DAYHOFF, MO
计算机程序被描述为帮助根据通过蛋白质水解获得的重叠肽的结构知识来确定蛋白质中的氨基酸序列。该程序旨在用于规划实验、定位实验错误、确定与实验数据一致的所有可能序列以及测试最终答案的可靠性。 Fortran 计算机程序系统接受实验肽结构数据并以可接受的化学语言呈现结果。描述了利用不同类型的实验信息来部分或完全确定序列的示例。准确的系统操作和数据呈现的可能性使得比现在使用的实验技术更广泛的吸引力。
Computer pro-grams are described to aid in determining the sequence of the amino acids in a protein from knowledge of the structure of overlapping peptides obtained by hydrolysis of the protein. The programs are designed for use in planning experiments, locating experimental errors, determining all possible sequences consistent with the experimental data and testing the reliability of the final answer. The system of Fortran computer programs accepts the experimental pep-tide structure data and presents results in acceptable chemical language. Examples are described utilizing different types of experimental information for partially or completely determining the sequence. The possibility of accurate systematic manipulation and presentation of data makes attractive a much wider range of experimental techniques than are now used.