Epidemiological and clinical characteristics of coronavirus disease (COVID-19) cases at a screening clinic during the early outbreak period: a single-centre study.
Epidemiological and clinical characteristics of coronavirus disease (COVID-19) cases at a screening clinic during the early outbreak period: a single-centre study.
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DOI：
10.1099/jmm.0.001231
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发表时间：
2020-08
影响因子：
3
通讯作者：
Nawaz M
中科院分区：
文献类型：
--
作者：
Khan M;Khan H;Khan S;Nawaz M
2019冠状病毒病（COVID-19）是由严重急性呼吸道冠状病毒2型（SARS-CoV-2）引起的传染病。该疾病于2019年12月在中国湖北省省会武汉市首次发现，此后在全球范围内传播，导致2019-2020年冠状病毒大流行。SARS-CoV-2与原始的SARS-CoV密切相关。它被认为是一种动物源性疾病。该病毒主要在密切接触中在人与人之间传播，通常通过咳嗽、打喷嚏或交谈产生的小飞沫传播。人们也可能通过触摸受污染的表面，然后触摸他们的脸而受到感染。COVID-19患者目前仍是主要感染源。一项流行病学调查表明，一般人群对SARS-CoV-2易感。这种疾病的范围从轻微到危及生命。发烧是最常见的症状，尽管老年人和患有合并症的人可能会在疾病后期出现发烧。其他常见的症状包括咳嗽、食欲不振、疲劳、呼吸急促、咳痰、肌肉和关节疼痛。观察到恶心、呕吐和腹泻等症状的比例各不相同。有些病例可能会迅速进展为急性呼吸窘迫综合征（ARDS）和/或多器官功能衰竭。无症状携带者和处于潜伏期的携带者也可能具有传染性。 确定在巴基斯坦白沙瓦三级保健医院筛查诊所就诊的COVID-19患者的流行病学和临床特征。 在这项描述性研究中，我们分析了在伊曼医学研究所新成立的新冠肺炎筛查诊所就诊的患者数据。任何报告新发发热和/或咳嗽的人都要在筛查诊所接受SARS-CoV-2检测。我们记录并分析了2020年3月15日至4月21日在巴基斯坦白沙瓦的Bullman医学研究所通过实时逆转录（RT）-PCR确诊的患者的人口统计学、流行病学和临床特征，包括年龄、性别、旅行史、临床特征、合并症和实验室数据。采集845例患者咽拭子和鼻拭子标本，提取RNA，采用RT-PCR方法检测SARS冠状病毒2型。 如上所述，共采集了845份标本。SARS-CoV-2阳性率为14.3%。男性和老年人的阳性率明显较高。121例SARS-CoV-2感染者中，平均年龄43.19岁（sd，17.57），男性感染者85例（70.25%）。 常见症状包括发热（88例，72%）、咳嗽（72例，59.5%）和呼吸急促（69例，57%）。 22名（18%）患者在过去14天内有巴基斯坦境外旅行史，其中大多数从沙特阿拉伯返回。 在这项单中心、前瞻性、描述性研究中，发热、咳嗽和呼吸急促是最常见的症状。高龄（>50岁）、慢性潜在合并症和旅行史可能是风险因素。因此，我们得出结论，病毒核酸扩增试验（NAAT）在筛选诊所中识别SARS-CoV-2感染方面发挥了重要作用，有助于隔离和聚集这些患者。
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Corona Virus-2 (SARS-CoV-2). The disease was first identified in December 2019 in Wuhan, the capital of China's Hubei province, and has since spread globally, resulting in the ongoing 2019–2020 corona virus pandemic. SARS-CoV-2 is closely related to the original SARS-CoV. It is thought to have a zoonotic origin. The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing or talking. People may also become infected by touching a contaminated surface and then touching their face. COVID-19 patients currently remain the primary source of infection. An epidemiological survey indicated that the general population is susceptible to SARS-CoV-2. The spectrum of this disease ranges from mild to life-threatening. Fever is the most common symptom, although older people and those with comorbidities may experience fever later in the disease. Other common symptoms include cough, loss of appetite, fatigue, shortness of breath, sputum production, and muscle and joint pains. Symptoms such as nausea, vomiting and diarrhea have been observed in varying percentages. Some cases might progress promptly to acute respiratory distress syndrome (ARDS) and/or multiple organ function failure. Asymptomatic carriers and those in the incubation period may also be infectious. To determine the epidemiological and clinical characteristics of patients presenting with COVID-19 at the screening clinic of a tertiary care hospital in Peshawar, Pakistan. In this descriptive study, we analysed data of patients presenting to a newly established Covid-19 screening clinic in Rehman Medical Institute. Anyone who reported with new onset fever and/or cough was tested for SARS-CoV-2 in the screening clinic. We documented and analysed demographic, epidemiological and clinical characteristics, which included age, sex, travel history, clinical features, comorbidities and laboratory data of patients confirmed by real-time reverse-transcription (RT)-PCR at Rehman Medical Institute, Peshawar, Pakistan from 15 March till 21 April 2020. Paired specimens of throat swabs and nasal swabs were obtained from 845 patients, ribonucleic acid (RNA) was extracted and tested for SARS-CoV-2 by the RT-PCR assay. A total of 845 specimens were taken as described above. The positive rate for SARS-CoV-2 was about 14.3%. Male and older population had a significantly higher positive rate. Of the 121 patients infected with SARS-CoV-2, the mean age was 43.19 years (sd, 17.57) and the infections were more frequent among male gender accounting for 85 (70.25 %) patients. Common symptoms included fever (88 patients, 72 %), cough (72 patients, 59.5 %) and shortness of breath (69 patients, 57 %). Twenty-two (18 %) patients had recent travel history outside Pakistan in the previous 14 days, the majority of whom had returned back from Saudi Arabia. In this single-centre, prospective, descriptive study, fever, cough and shortness of breath were the most common symptoms. Old age (>50 years), chronic underlying comorbidities and travel history may be risk factors. Therefore, we concluded that viral nucleic acid amplification tests (NAAT) played an important role in identifying SARS-CoV-2 infection in a screening clinic, which helped with isolation and cohorting of these patients.
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影响因子：
5.4
作者：
Sexton, Nicole R.;Smith, Everett Clinton;Denison, Mark R.
通讯作者：
Denison, Mark R.
影响因子：
1.6
作者：
Johnson, HD;Sholcosky, D;Ogonosky, N
通讯作者：
Ogonosky, N
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung