Nuclear bodies: multifunctional companions of the genome.
Nuclear bodies: multifunctional companions of the genome.
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DOI：
10.1016/j.ceb.2012.03.010
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发表时间：
2012-06
影响因子：
7.5
通讯作者：
Dundr, Miroslav
中科院分区：
文献类型：
--
作者：
Dundr, Miroslav
越来越明显的是，基因表达受空间基因组组织和核结构之间的功能相互作用的调控。在核环境中，存在着各种不同的核体。它们是动态的自组织结构，不以预先形成的实体的形式组装，而是作为与基因表达和基因组维护相关的特定活动的直接反映而出现。在这里，我总结了一些最重要的核体功能的最新发现，包括核仁、Cajal体、PML核体、Polycomb群体和53BP1核体。新出现的观点认为，它们的组织是由类似的原则编排的，它们在涉及动态平衡、分化、发育和疾病的基本细胞过程中发挥作用。
It has become increasingly apparent that gene expression is regulated by the functional interplay between spatial genome organization and nuclear architecture. Within the nuclear environment a variety of distinct nuclear bodies exist. They are dynamic, self-organizing structures that do not assemble as pre-formed entities but rather emerge as a direct reflection of specific activities associated with gene expression and genome maintenance. Here I summarize recent findings on functions of some of the most prominent nuclear bodies, including the nucleolus, Cajal body, PML nuclear body, Polycomb group body and the 53BP1 nuclear body. The emerging view is that their organization is orchestrated by similar principles, and they function in fundamental cellular processes involved in homeostasis, differentiation, development and disease.
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DOI：
10.1083/jcb.201105143
发表时间：
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期刊：
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