Identification and evaluation of high-titer anti-Sox Group B antibody in limbic encephalitis
Identification and evaluation of high-titer anti-Sox Group B antibody in limbic encephalitis
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DOI：
10.2492/inflammregen.27.37
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发表时间：
2007-01
影响因子：
8.1
通讯作者：
H. Tada;Seiji Ishii;Hiroaki Kimura;H. Hattori;Y. Okada;N. Suzuki;H. Okano
中科院分区：
文献类型：
--
作者：
H. Tada;Seiji Ishii;Hiroaki Kimura;H. Hattori;Y. Okada;N. Suzuki;H. Okano
我们评估了在一名可能患有肺癌的边缘脑炎患者中检测到的高滴度自身抗体。患者的自身抗体与侧脑室室下区和海马齿状回（成人大脑的神经源性区域）中掺有 BrdU 的分裂细胞发生反应，大多数免疫反应细胞被认为是原神经细胞。通过蛋白质印迹和免疫吸收对自身抗原进行表征表明，患者血清中的抗体与 Sox B 组蛋白结合，但不与真正的副肿瘤抗原结合。我们的结果表明，神经干/祖细胞群将成为成人大脑中自身抗体的目标。
We evaluated a high titer autoantibody detected in a limbic encephalitis patient with possible lung carcinoma. The patient's autoantibody reacted with BrdU-incorporated dividing cells in the subventricular zone of lateral ventricle and dentate gyrus of the hippocampus, the neurogenic regions of the adult brain, and most of the immunoreactive cells are thought be proneural cells. Characterization of the autoantigen by Western blotting and immunoabsorption has shown that the antibody in the patient's serum binds to Sox Group B proteins but not to authentic paraneoplastic antigens. Our results indicate that the neural stem/progenitor cell population would be a target of the autoantibody in the adult brain.