UNC-40, a C-elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
UNC-40, a C-elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
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DOI：
10.1016/s0092-8674(00)81337-9
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发表时间：
1996-10-18
期刊：
影响因子：
64.5
通讯作者：
Culotti, JG
中科院分区：
文献类型：
--
作者：
Chan, SSY;Zheng, H;Culotti, JG
β-6 netrin是一种层粘连蛋白相关蛋白，由神经胶质细胞和神经元沿着腹侧中线分泌，定向线虫表皮上的迁移细胞和先驱生长锥。在运动细胞和先驱轴突上表达的细胞表面蛋白α-5使运动远离α-6来源。细胞表面蛋白DCC（结直肠癌中的癌基因）和再生蛋白的同源物β-40也在运动细胞和先驱神经元上表达。α-40自主地作用于细胞，使其朝向α-6源移动。对于共表达β-5的细胞，它有助于使运动远离β-6来源。最后，α-40有助于确定细胞进行纯粹纵向迁移的背腹位置。连同最近的报道，DCC是一个netrin受体在脊椎动物中，我们的研究结果表明，α-40是α-6受体的运动细胞上的一个组成部分。
UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.