Total Fat Intake Is Associated with Decreased Mortality in Japanese Men but Not in Women
Total Fat Intake Is Associated with Decreased Mortality in Japanese Men but Not in Women
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DOI：
10.3945/jn.112.161661
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发表时间：
2012-09-01
影响因子：
4.2
通讯作者：
Kawachi, Toshiaki
中科院分区：
文献类型：
--
作者：
Nagata, Chisato;Nakamura, Kozue;Kawachi, Toshiaki
饮食指南通常建议避免高脂肪饮食。然而，脂肪亚型与死亡率之间的关系仍不清楚，特别是在脂肪摄入量相对较低的人群中。我们的目的是前瞻性地研究日本社区膳食脂肪摄入量与全因和特定原因死亡率之间的关系。 1992 年，日本高山市共有 28,356 名没有癌症、中风或冠心病的居民对经过验证的 169 项 FFQ 做出了回应。我们在 16 年的随访期间发现了 4616 例死亡。在控制潜在的混杂因素后，根据脂肪总量和脂肪亚型替代等能量碳水化合物时的能量百分比计算死亡率 HR。高总脂肪和多不饱和脂肪酸的摄入量与男性全因死亡率的降低有关；最高五分位数与最低五分位数相比的 HR 为 0.83，195% CI：0.70，0.99；总脂肪的 P-趋势 = 0.048）和 PUFA 的 0.77（95% CI：0.62, 0.95；P-趋势 = 0.051）。这两种脂肪都与癌症和心血管疾病以外的其他疾病的死亡率降低相关。在女性中，较高的 SFA 摄入量与较高的全因死亡率相关（FIR = 1.22（95% CI：0.99, 1.49；P-trend = 0.051）。 P-趋势 = 0.03)]。有人认为，除心血管疾病外，总脂肪和 PUFA 摄入量对男性死亡率有有利影响，而 SFA 摄入量增加可能与女性的不良健康后果有关。
Dietary guidelines generally recommend avoiding a high-fat diet. However, the relationship between fat subtypes and mortality remains unclear especially in a population with a relatively low intake of fat. We aimed to prospectively examine the relationship between dietary fat intake and all-cause and cause-specific mortality in a Japanese community. In 1992, a total of 28,356 residents of Takayama, Japan, without cancer, stroke, or coronary heart disease, responded to a validated 169-item FFQ. We identified 4616 deaths during a 16-y follow-up. The HR of mortality according to the percentage of energy from the total and subtypes of fat when substituted for an isoenergic quantity of carbohydrate was calculated after controlling for potential confounders. A high intake of total fat and PUFA was associated with a decrease in all-cause mortality in men; the HR for the highest compared with the lowest quintile were 0.83 195% CI: 0.70, 0.99; P-trend = 0.048) for total fat and 0.77 (95% CI: 0.62, 0.95; P-trend = 0.051 for PUFA. Both fats were associated with a decrease in mortality from cancer and diseases other than cardiovascular disease. In women, a higher SFA intake was associated with higher allcause mortality (FIR = 1.22 (95% CI: 0.99, 1.49; P-trend = 0.03)]. A favorable effect was suggested for total fat and PUFA intakes on mortality in men except for that from cardiovascular disease, whereas increased SFA intake may be associated with adverse health consequences in women. J. Nutr. 142: 1713-1719, 2012.