Disrupted prefrontal activity during emotion processing in complicated grief: An fMRI investigation.
Disrupted prefrontal activity during emotion processing in complicated grief: An fMRI investigation.
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DOI：
10.1016/j.neuroimage.2015.09.054
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发表时间：
2016-01-01
期刊：
影响因子：
5.7
通讯作者：
O'Connor MF
中科院分区：
文献类型：
--
作者：
Arizmendi B;Kaszniak AW;O'Connor MF
复杂的悲伤，以持续超过预期适应期的持续和侵入性悲伤为标志，与相对无法摆脱具体的与损失相关的刺激有关。在其他人群中，研究与这种偏见相关的神经网络的功能磁共振成像(FMRI)研究一致地表明，在情绪调节过程中，前扣带皮质(ACC)也有影响。在这项研究中，28名老年人根据悲伤的严重程度被分为三组：复杂悲伤(n=8)，非复杂悲伤(n=9)，以及非丧亲已婚对照组(n=11)。使用区块设计，所有参与者在fMRI数据采集期间完成了ecStroop任务的8个区块(每个区块20个刺激)。研究人员检查了不同组别在悲伤相关(与中性相反)刺激时神经活动的差异。与对照组相比，那些有复杂悲伤的患者显示没有增加的吻侧ACC(RACC)和额叶皮质招募。与未丧失亲人的对照组相比，无并发症悲伤组的眼眶前额叶皮质(x=6，y=54，z=−10)的活动显著增加。事后分析证明，在复杂的悲痛和未丧失亲人的组中，任务后期的背侧ACC中有活动。这些发现得到了行为数据的支持，表明在那些有复杂悲伤的人中，他们相对无法招募成功完成这项情感任务所需的区域。在非复杂性悲伤中，在处理特定语义刺激的过程中，在眼眶前额叶皮质和rACC的招募中没有观察到这种缺陷。
Complicated Grief, marked by a persistent and intrusive grief lasting beyond the expected period of adaptation, is associated with a relative inability to disengage from idiographic loss-relevant stimuli. In other populations, functional magnetic resonance imaging (fMRI) studies investigating the neural networks associated with this bias consistently implicate the anterior cingulate cortex (ACC) during emotion regulation. In the present study, twenty-eight older adults were categorized into three groups based on grief severity: Complicated Grief (n=8), Non-Complicated Grief (n=9), and Nonbereaved, married controls (n=11). Using a block design, all participants completed 8 blocks (20 stimuli per block) of the ecStroop task during fMRI data acquisition. Differences in neural activity during grief-related (as opposed to neutral) stimuli across groups were examined. Those with Complicated Grief showed an absence of increased rostral ACC (rACC) and fronto-cortical recruitment relative to Nonbereaved controls. Activity in the orbitofrontal cortex (x=6, y=54, z=−10) was significantly elevated in the Non-Complicated Grief group when compared to Nonbereaved controls. Post hoc analysis evidenced activity in the dorsal ACC in the Complicated Grief and Nonbereaved groups late in the task. These findings, supported by behavioral data, suggest a relative inability to recruit the regions necessary for successful completion of this emotional task in those with Complicated Grief. This deficit was not observed in recruitment of the orbitofrontal cortex and the rACC during processing of idiographic semantic stimuli in Non-Complicated Grief.