Association of anxious and depressive symptoms with medication nonadherence in patients with stable coronary artery disease
Association of anxious and depressive symptoms with medication nonadherence in patients with stable coronary artery disease
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DOI：
10.1016/j.jpsychores.2012.12.003
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发表时间：
2013-02-01
影响因子：
4.7
通讯作者：
Schultz, Jobst-Hendrik
中科院分区：
文献类型：
--
作者：
Dempe, Christian;Juenger, Jana;Schultz, Jobst-Hendrik
目的：抑郁和焦虑导致冠状动脉疾病（CAD）患者发病率和死亡率增加。药物不依从是导致不良结局的一个可能途径，但与抑郁-焦虑合并症相比，抑郁或焦虑本身如何影响依从性尚不清楚。本研究的目的是评估同时抑郁和焦虑症状对稳定型CAD患者药物依从性的影响。方法：在2009年2月至2010年6月期间，我们对606例稳定型CAD住院患者进行了横断面研究，研究了当前抑郁和焦虑症状与药物不依从性之间的关系。采用医院焦虑和抑郁量表评估症状。结果：抑郁和焦虑症状与药物不依从性呈弱相关（r=0.28，p
Objective:. Depression and anxiety lead to increased morbidity and mortality in patients with coronary artery disease (CAD). Medication nonadherence is one possible pathway contributing to adverse outcome, but it is unknown how either depression or anxiety itself influences adherence compared to combined depressive-anxious comorbidity. The aim of the study was to evaluate the influence of simultaneous depressive and anxious symptoms on medication adherence in patients with stable CAD.Methods: Between 02/2009 and 06/2010 we examined the association between current depressive and anxious symptoms with medication nonadherence in a cross-sectional study of 606 inpatients with stable CAD. Symptoms were assessed by using the Hospital Anxiety and Depression Scale. Morisky Medical Adherence Scale measured medication adherence.Results: Depressive and anxious symptoms were weakly and independently associated with medication nonadherence (r=0.28, p