Predictors of congestive heart failure in the elderly: The cardiovascular health study
Predictors of congestive heart failure in the elderly: The cardiovascular health study
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DOI：
10.1016/s0735-1097(00)00582-9
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发表时间：
2000-05-01
影响因子：
24
通讯作者：
Boineau, RC
中科院分区：
文献类型：
--
作者：
Gottdiener, JS;Arnold, AM;Boineau, RC
目的 我们试图描述社区老年人群中发生充血性心力衰竭 (CHF) 的预测因素，这些预测因素由中央裁决确定。 背景 在因 CHF 入院的患者中，老年人所占的比例越来越大，而 CHF 是该群体发病率和死亡率的主要来源。老年患者与诊断为 CHF 的年轻患者在生物学特征方面有所不同。 方法 我们分析了心血管健康研究的数据，这是一项基于人群的前瞻性研究，在四个地点对 5,888 名 65 岁以上的老年人（平均 73 +/- 5，范围 65 至 100）进行了研究。获得了心血管结构和功能、血液化学和功能评估的多项实验室测量结果。 结果 在平均 5.5 年（中位数 6.3）的随访期间，597 名参与者发生了 CHF（发生率 19.3/1,000 人年）。 CHF 的发病率在各个年龄组中逐渐增加，男性高于女性。在多变量分析中，其他独立预测因素包括基线时流行的冠心病、中风或短暂性脑缺血发作、糖尿病、收缩压 (BP)、用力呼气量 1 s、肌酐 >1.4 mg/dl、C 反应蛋白、踝臂指数
OBJECTIVES We sought to characterize the predictors of incident congestive heart failure (CHF), as determined by central adjudication, in a community-based elderly population.BACKGROUND The elderly constitute a growing proportion of patients admitted to the hospital with CHF, and CHF is a leading source of morbidity and mortality in this group. Elderly patients differ from younger individuals diagnosed with CHF in terms of biologic characteristics.METHODS We analyzed data from the Cardiovascular Health Study, a prospective population-based study of 5,888 elderly people >65 years old (average 73 +/- 5, range 65 to 100) at four locations. Multiple laboratory measures of cardiovascular structure and function, blood chemistries and functional assessments were obtained.RESULTS During an average follow-up of 5.5 years (median 6.3), 597 participants developed incident CHF (rate 19.3/1,000 person-years). The incidence of CHF increased progressively across age groups and was greater in men than in women. On multivariate analysis, other independent predictors included prevalent coronary heart disease, stroke or transient ischemic attack at baseline, diabetes, systolic blood pressure (BP), forced expiratory volume 1 s, creatinine >1.4 mg/dl, C-reactive protein, ankle-arm index