LEFT-VENTRICULAR DIASTOLIC FILLING PERFORMANCE IN OLDER MALE-ATHLETES
LEFT-VENTRICULAR DIASTOLIC FILLING PERFORMANCE IN OLDER MALE-ATHLETES
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DOI：
10.1001/jama.273.17.1371
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发表时间：
1995-05-03
影响因子：
120.7
通讯作者：
LAKATTA, EG
中科院分区：
文献类型：
--
作者：
FLEG, JL;SHAPIRO, EP;LAKATTA, EG
目标。目的：确定与久坐不动的同龄人相比，接受多年高强度耐力训练的老年男性是否表现出更少的与年龄相关的早期左心室舒张期（LV）充盈功能损害。-横断面前瞻性研究。-社区研究志愿者，参与者。-来自巴尔的摩老龄化纵向研究的16名年龄在52至76岁之间的年长竞技男性耐力运动员，17名年轻（40岁）和23名年长（52至76岁）久坐的对照组受试者。-所有受试者在分级跑步机运动期间接受静息多普勒超声心动图检查并测定最大有氧能力（Vo(2)max）。多普勒超声心动图研究在不了解受试者年龄或运动习惯的情况下进行解释。主要结果测量。-多普勒衍生的左室舒张充盈性能测量：早期(E)充盈速度峰值，晚期(A)充盈速度峰值，E峰与A峰速度之比（E/A），心房充盈分数。老年运动员的Vo(2)max （47+/-6 mL/kg /分钟[平均值+/-SD]）高于年轻对照组（41 +/-7 mL/kg /分钟）或老年对照组（30+/-7 mL/kg /分钟）
Objective.-To determine whether older men who have undergone intensive endurance training over many years demonstrate less age-associated impairment of early diastolic left ventricular (LV) filling performance than their sedentary peers.Design.-Cross-sectional prospective study.Setting.-Community-dwelling research volunteers.Participants.-Sixteen older competitive male endurance athletes aged 52 through 76 years and 17 young (40 years) and 23 older (52 through 76 years) sedentary control subjects from the Baltimore Longitudinal Study of Aging.Intervention.-All subjects underwent resting Doppler echocardiography and determination of maximal aerobic capacity (Vo(2)max) during graded treadmill exercise. Doppler echocardiographic studies were interpreted without knowledge of the subject's age or exercise habits.Main Outcome Measures.-Doppler-derived measures of LV diastolic filling performance: peak early (E) filling velocity, peak late (A) filling velocity, ratio of peak E to peak A velocities (E/A), and atrial filling fraction.Results.-Older athletes demonstrated higher Vo(2)max (47+/-6 mL/kg per minute [mean+/-SD]) than either the young controls (41 +/-7 mL/kg per minute) or older controls (30+/-7 mL/kg per minute) (P