99mTc-MIBI scintigraphy of parathyroid adenomas and its relation to tumour size and oxyphil cell abundance
99mTc-MIBI scintigraphy of parathyroid adenomas and its relation to tumour size and oxyphil cell abundance
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DOI：
10.1007/s002590000406
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发表时间：
2001-02-01
期刊：
影响因子：
--
通讯作者：
Gal, R
中科院分区：
文献类型：
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作者：
Melloul, M;Paz, A;Gal, R
本研究的目的是评估甲状旁腺瘤对锝-99m甲氧基异丁基异腈（MIBI）的摄取与氧细胞含量和病变体积之间的关系。对31例甲状旁腺瘤患者进行前瞻性评价。术前对所有患者进行双期99mTc-MIBI显像，并采用感兴趣区域与正常相邻颈部区域的比值半定量评估甲状旁腺病变的示踪剂摄取。手术标本进行组织学评估和氧细胞含量测定。将示踪剂摄取强度与嗜氧细胞含量、病变体积、血清钙和甲状旁激素水平进行比较。99mTc-MIBI示踪剂摄取与氧基细胞含量、甲状旁腺病变体积及甲状旁腺瘤功能状态相关，示踪剂在氧基细胞中的积累可能部分解释了99mTc-MIBI在甲状旁腺病变中的优先滞留。
The aim of this study was to assess the correlation between technetium-99m methoxyisobutylisonitrile (MIBI) uptake by parathyroid adenomas, oxyphil cell content and volume of the lesions. Thirty-one patients with parathyroid adenomas were evaluated prospectively. Preoperative double-phase 99mTc-MIBI scintigraphy was performed in all patients and tracer uptake by parathyroid lesions was assessed semi-quantitatively employing region of interest ratios to normal adjacent neck areas. Surgical specimens underwent histological evaluation and oxyphil cell content was determined. The intensity of tracer uptake was compared with oxyphil cell content, volume of the lesions and serum levels of calcium and parathormone. 99mTc-MIBI tracer uptake was correlated with oxyphil cell content, volume of parathyroid lesions and the functional status of the parathyroid adenomas, Tracer accumulation in oxyphil cells might partially explain the preferential 99mTc-MIBI retention in parathyroid lesions.