Implications of stromal-epithelial interaction in human prostate cancer growth, progression and differentiation.
Implications of stromal-epithelial interaction in human prostate cancer growth, progression and differentiation.
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发表时间：
1993-06
影响因子：
14.5
通讯作者：
Leland W.K. Chung
中科院分区：
文献类型：
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作者：
Leland W.K. Chung
前列腺癌是最常见的恶性肿瘤，也是美国男性癌症死亡的第二大原因。前列腺癌最有趣的方面之一是，尽管在世界各地的男性中检测到的潜伏性前列腺癌的发病率相似，但这种疾病的临床进展率存在显着差异。生活在北美的男性有明显的疾病进展，而生活在日本或中国的男性则没有。在本文中，讨论了可能在确定前列腺癌生长和进展速率中发挥关键作用的潜在表观遗传因素。我们认为基质-上皮相互作用可能对前列腺癌的生长及其侵袭性表型的表达至关重要。此外，我们已经证明，向已建立的非致瘤性前列腺上皮细胞系（但不是正常前列腺上皮细胞）输送适当的生长因子和/或细胞外基质可能会加速疾病进展，并可能不可逆地影响前列腺上皮细胞行为。
Prostate cancer is the most common malignancy and the second leading cause of cancer death in American men. One of the most intriguing aspects of prostate cancer is that despite the similar high incidence of latent forms of prostate cancer detected in men throughout the world, remarkable disparity exists in the rate of clinical progression of this disease. Men living in North America have significant disease progression, whereas men living in Japan or China do not. In this article, the potential epigenetic factors that may play a critical role in determining the rate of prostate cancer growth and progression is discussed. We propose that stromal-epithelial interaction may be of fundamental importance to prostate cancer growth and expression of its invasive phenotypes. Furthermore, we have demonstrated that delivering appropriate growth factor(s) and/or extracellular matrice(s) to an established non-tumorigenic prostatic epithelial cell line (but not normal prostatic epithelial cells) may accelerate disease progression and may irreversibly affect prostatic epithelial cell behavior.