Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis.
Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis.
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DOI：
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发表时间：
1996-03
期刊：
影响因子：
11.2
通讯作者：
T. Brentnall;David A. Crispin;M. Bronner;Sajeev P. Cherian;Molly Hueffed;P. Rabinovitch;C. Rubin;
中科院分区：
文献类型：
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作者：
T. Brentnall;David A. Crispin;M. Bronner;Sajeev P. Cherian;Molly Hueffed;P. Rabinovitch;C. Rubin;
微卫星不稳定性（MIN）已在许多癌症类型中检测到；然而，最近我们也在非肿瘤性但炎症性的胰腺炎中观察到它。因此，我们试图检查MIN是否存在于另一种炎症状态，溃疡性结肠炎（UC）。50%的UC患者结肠黏膜发育不良阴性，46%的高度发育不良患者，40%的癌症患者（但没有缺血性或感染性结肠炎对照）发现MIN （P<0.03）。因此，UC患者可能在粘膜内有MIN，但没有组织学证据表明有肿瘤改变。在这种情况下，MIN可能反映了DNA修复机制无法补偿慢性炎症的压力，并且可能是UC肿瘤风险增加的机制之一。
Microsatellite instability (MIN) has been detected in many cancer types; however, recently we also observed it in the nonneoplastic but inflammatory setting of pancreatitis. Consequently, we sought to examine whether MIN was present in another inflammatory condition, ulcerative colitis (UC). MIN was found in 50% of UC patients whose colonic mucosa was negative for dysplasia, 46% of those with high-grade dysplasia, and 40% of those with cancer but in none of the ischemic or infectious colitis controls (P<0.03). Thus, UC patients may have MIN within mucosa that has no histological evidence of neoplastic change. MIN in this setting may reflect the inability of DNA repair mechanisms to compensate for the stress of chronic inflammation, and may be one mechanism for the heightened neoplastic risk in UC.