Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?
Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?
复制标题
病毒感染期间的细胞毒性CD4 T细胞或敌人或敌人？
DOI：
10.3389/fimmu.2017.00019
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发表时间：
2017
影响因子：
7.3
通讯作者：
Munier CM
中科院分区：
文献类型：
--
作者：
Juno JA;van Bockel D;Kent SJ;Kelleher AD;Zaunders JJ;Munier CM
具有细胞毒性功能的CD4 T细胞曾被认为是长期体外培养的产物，但近年来已被接受，并在文献中报道了对许多病毒感染的反应。在这篇综述中，我们主要关注细胞毒性CD4 T细胞在人类病毒感染以及影响小鼠和非人灵长类动物的一些感染中的作用。我们研究了细胞毒性CD4细胞使用的效应机制，描述这一群体的表型，以及导致其在感染后诱导的转录因子和途径。我们进一步考虑作为该效应亚群主要靶点的细胞，并描述CD4细胞毒性T淋巴细胞已被证明发挥保护或病理作用的病毒感染。细胞毒性CD4 T细胞在循环中被检测到的水平比以前认识到的要高得多，现在被认为在对病毒感染的免疫反应中起着重要作用。
CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in vitro cultures but have in more recent years become accepted and reported in the literature in response to a number of viral infections. In this review, we focus on cytotoxic CD4 T cells in the context of human viral infections and in some infections that affect mice and non-human primates. We examine the effector mechanisms used by cytotoxic CD4 cells, the phenotypes that describe this population, and the transcription factors and pathways that lead to their induction following infection. We further consider the cells that are the predominant targets of this effector subset and describe the viral infections in which CD4 cytotoxic T lymphocytes have been shown to play a protective or pathologic role. Cytotoxic CD4 T cells are detected in the circulation at much higher levels than previously realized and are now recognized to have an important role in the immune response to viral infections.