Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome
Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome
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DOI：
10.1016/j.leukres.2011.11.012
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发表时间：
2012-03-01
影响因子：
2.7
通讯作者：
Pagano, Livio
中科院分区：
文献类型：
--
作者：
Fianchi, Luana;Leone, Giuseppe;Pagano, Livio
由于粒细胞的定量和定性缺陷，感染是骨髓增生异常综合征 (MDS) 患者发病和死亡的主要原因。我们评估了从 MDS 中分离出的中性粒细胞的体外杀菌和杀真菌活性。与健康个体相比，感染后的 MDS 中性粒细胞在 8 小时（p = 0.002）、24 小时（p < 0.0001）、48 小时（p = 0.0005）和 72 小时（p = 0.0264）时对大肠杆菌的杀灭活性显着降低，对乳酸乳球菌在 24 小时（p = 0.0002）时的杀灭活性显着降低。 48 (p < 0.0001) 和 72 小时 (p < 0.0001），以及在 8 小时（p = 0.0003）、24 小时（p < 0.0001）、48 小时（p < 0.0001）和 72 小时（p < 0.0001）时针对白色念珠菌的效果更高。我们的数据显示MDS中性粒细胞的杀菌功能受损，这可能是MDS患者对感染高度敏感的原因。 (C) 2011 Elsevier Ltd. 保留所有权利。
Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndrome (MDS) due to quantitative and qualitative granulocytic defects. We evaluated the in vitro bactericidal and fungicidal activities of neutrophils isolated from MDS. With comparison to those from healthy individuals, MDS neutrophils following infection showed a significantly reduced killing activity against Escherichia coli at 8 (p = 0.002), 24 (p < 0.0001), 48 (p = 0.0005), and 72 h (p = 0.0264), against Lactococcus lactis at 24 (p = 0.0002), 48 (p < 0.0001), and 72 h (p < 0.0001), and more against Candida albicans at 8 (p = 0.0003), 24 (p < 0.0001), 48 (p < 0.0001), and 72 h (p < 0.0001). Our data show that MDS neutrophils have an impaired microbicidal function, which might account for the high susceptibility to infections of MDS patients. (C) 2011 Elsevier Ltd. All rights reserved.