EFFECT OF MEAN CIRCULATORY FILLING PRESSURE AND OTHER PERIPHERAL CIRCULATORY FACTORS ON CARDIAC OUTPUT
EFFECT OF MEAN CIRCULATORY FILLING PRESSURE AND OTHER PERIPHERAL CIRCULATORY FACTORS ON CARDIAC OUTPUT
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DOI：
10.1152/ajplegacy.1955.180.3.463
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发表时间：
1955-01-01
影响因子：
--
通讯作者：
KAUFMANN, BN
中科院分区：
文献类型：
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作者：
GUYTON, AC;LINDSEY, AW;KAUFMANN, BN
方法犬47只，戊巴比妥钠麻醉，肝素3 mg/kg肝素化。通过插入动脉和静脉系统的导管，分别用水银压力计和水压计测量动脉和右房压力。在15个实验中，狗的心脏被窒息停止，在右心房壁上用钱包线缝合一个特殊的插管，用变量推进泵将血液通过外部电路泵入，用频闪血流计测量血流量，最终血液通过插管直接返回到近端主动脉。直到血管运动活动的所有迹象消失后，才在这些动物身上进行实验。在这些实验中，通过增加或减少循环系统中的血液来改变平均循环充盈压，通过改变外泵的推进力或改变外系统中的阻力程度来改变右心房压。在21只活体动物上进行了与上述类似的实验，血液从上下腔静脉的导管通过外部回路被泵出，然后通过上腔静脉的心端回到右心房。
METHODSForty-seven dogs anesthetized with sodium pentobarbital and heparinized with 3 mg/kg of heparin were used in the present experiments. Arterial and right atria1 pressures were measured by mercury and water manometers through catheters inserted into the arterial and venous systems, respectively. In 15 of the experiments the dogs’ hearts were stopped by asphyxiation, a special cannula was fixed by a purse string suture in the wall of the right atrium, blood was pumped through an external circuit by a variable propulsion pump, blood flow was measured by a stromuhr type flowmeter, and the blood was eventually returned through a cannula directly intc the proximal aorta. Experiments in these animals were not performed until all signs of vasomotor activity were gone. In these experiments the mean circulatory filling pressure was varied by increasing or decreasing the blood in the circulatory system, and the right atria1 pressure was varied by changing the propulsive force of the external pump or by changing the degree of resistance in the external system. Experiments similar to those performed above on dead animals were performed on 21 live dogs while blood was pumped from cannulae in the superior and inferior vena cavae through an external circuit and then back into the right atrium through the cardiac end of the superior vena cava.