Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation.
Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation.
复制标题
DOI：
10.1016/j.nlm.2011.03.001
复制
发表时间：
2011-07
影响因子：
2.7
通讯作者：
Lubin, Farah D.
中科院分区：
文献类型：
--
作者：
Lubin, Farah D.
脑源性神经营养因子(BDNF)是长期记忆形成所必需的众多基因产物之一，其调节失调与认知和精神障碍的发病机制密切相关。最近的工作表明，表观遗传调控机制，包括组蛋白和相关DNA的标记，在整个生命周期中保持不稳定，并代表着有助于大脑基因调控的一个有吸引力的分子过程。在这篇综述中，重要的信息将讨论表观遗传学作为一套新发现的动态转录机制，用于调节成人大脑中基因表达的变化，特别是BDNF在学习和记忆形成中的转录读出。这篇综述还将突出表观遗传学在异常的BDNF基因调控中在癫痫障碍、Rett综合征、精神分裂症和阿尔茨海默病相关的认知功能障碍发病机制中的作用的证据。这项研究为理解有助于成人认知和心理健康的表观遗传转录机制提供了新的概念，并为临床治疗方法提供了新的途径。
Brain-derived neurotrophic factor (bdnf) is one of numerous gene products necessary for long-term memory formation and dysregulation of bdnf has been implicated in the pathogenesis of cognitive and mental disorders. Recent work indicates that epigenetic-regulatory mechanisms including the markings of histone proteins and associated DNA remain labile throughout the lifespan and represent an attractive molecular process contributing to gene regulation in the brain. In this review, important information will be discussed on epigenetics as a set of newly identified dynamic transcriptional mechanisms serving to regulate gene expression changes in the adult brain with particular emphasis on bdnf transcriptional readout in learning and memory formation. This review will also highlight evidence for the role of epigenetics in aberrant bdnf gene regulation in the pathogenesis of cognitive dysfunction associated with seizure disorders, Rett syndrome, Schizophrenia, and Alzheimer’s disease. Such research offers novel concepts for understanding epigenetic transcriptional mechanisms subserving adult cognition and mental health, and furthermore promises novel avenues for therapeutic approach in the clinic.
登录
查看更多内容
Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
2
作者：
Ahn, Hyung Jin;Hernandez, Caterina M.;Sweatt, J. David
通讯作者：
Sweatt, J. David
影响因子：
64.8
作者：
Barreto, Guillermo;Schaefer, Andrea;Niehrs, Christof
通讯作者：
Niehrs, Christof
影响因子：
5.3
作者：
Colvis, CM;Pollock, JD;Nestler, EJ
通讯作者：
Nestler, EJ
影响因子：
2
作者：
Chwang, Wilson B.;O'Riordan, Kenneth J.;Sweatt, J. David
通讯作者：
Sweatt, J. David