At the intersection of attention and memory: The mechanistic role of the posterior parietal lobe in working memory
At the intersection of attention and memory: The mechanistic role of the posterior parietal lobe in working memory
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DOI：
10.1016/j.neuropsychologia.2011.02.033
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发表时间：
2011-04-01
期刊：
影响因子：
2.6
通讯作者：
Olson, Ingrid R.
中科院分区：
文献类型：
--
作者：
Berryhill, Marian E.;Chein, Jason;Olson, Ingrid R.
部分后顶叶皮层（PPC）在工作记忆（WM）中发挥作用，但该区域的确切机制功能尚不清楚。纯存储假说认为，这一区域的功能是短期的特定模式的记忆存储。另外，内部注意假说认为，PPC是一种基于注意的存储和刷新机制，可作为特定材料排练的替代方案。这些模型在双侧PPC病变患者中进行了测试。我们的研究结果否定了纯存储假说，因为索引存储容量和寿命的变量并没有不成比例地受到PPC损伤的影响。相反，我们的数据通过显示(a)正常参与者倾向于在回忆任务中使用基于预演的WM维持策略，而不是在识别任务中使用；(b) PPC病变患者在依赖于材料特异性预演策略的WM任务中表现正常，但在依赖于基于注意的维持策略的WM任务中表现不佳，患者策略的使用可能因任务或指令而改变；(c)患者的记忆缺陷扩展到长时域。这些发现表明，在WM中，PPC维持或转移了项目表征之间的内部注意。(C) 2011 Elsevier Ltd.版权所有。
Portions of the posterior parietal cortex (PPC) play a role in working memory (WM) yet the precise mechanistic function of this region remains poorly understood. The pure storage hypothesis proposes that this region functions as a short-lived modality-specific memory store. Alternatively, the internal attention hypothesis proposes that the PPC functions as an attention-based storage and refreshing mechanism deployable as an alternative to material-specific rehearsal. These models were tested in patients with bilateral PPC lesions. Our findings discount the pure storage hypothesis because variables indexing storage capacity and longevity were not disproportionately affected by PPC damage. Instead, our data support the internal attention account by showing that (a) normal participants tend to use a rehearsal-based WM maintenance strategy for recall tasks but not for recognition tasks; (b) patients with PPC lesions performed normally on WM tasks that relied on material-specific rehearsal strategies but poorly on WM tasks that relied on attention-based maintenance strategies and patient strategy usage could be shifted by task or instructions; (c) patients' memory deficits extended into the long-term domain. These findings suggest that the PPC maintains or shifts internal attention among the representations of items in WM. (C) 2011 Elsevier Ltd. All rights reserved.