Particle agglomeration in high shear mixers
Particle agglomeration in high shear mixers
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DOI：
10.1016/s0032-5910(96)03123-3
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发表时间：
1996-09-01
影响因子：
5.2
通讯作者：
Kristensen, HG
中科院分区：
文献类型：
--
作者：
Kristensen, HG
讨论了细粉在高剪切混合器中间歇造粒的团聚机理和液体要求。许多实验已经揭示了附聚物的液体饱和度与生长速率之间的密切相关性。饱和度由粘合剂液体的量和颗粒堆积密度决定。其对附聚物生长的影响可应用于分析，例如，混合器规模和加工条件对液体需求和最终颗粒尺寸的影响。生长动力学的研究表明，细粉末的团聚可能导致均匀尺寸的球形颗粒。这可以应用于改进释放产品的开发。
Agglomeration mechanisms and liquid requirements in the batch granulation of fine powders in high shear mixers are discussed. Many experiments have revealed a close correlation between the degree of liquid saturation of the agglomerates and the growth rate. The saturation degree is determined by the amount of binder liquid and the particle packing density. Its effects on the agglomerate growth can be applied in the analysis of, for example, effects of mixer scale and processing conditions on liquid requirements and the final granule size. Studies of the growth kinetics show that agglomeration of fine powders may result into uniformly sized granules of spherical shape. This can be applied in the development of modified release products.