Electrochemical Intramolecular C-H Amination: Synthesis of Benzoxazoles and Benzothiazoles
Electrochemical Intramolecular C-H Amination: Synthesis of Benzoxazoles and Benzothiazoles
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DOI：
10.1002/chem.201406398
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发表时间：
2015-02-16
影响因子：
4.3
通讯作者：
Yoshida, Jun-ichi
中科院分区：
文献类型：
--
作者：
Morofuji, Tatsuya;Shimizu, Akihiro;Yoshida, Jun-ichi
发展了一种无金属的分子内C-H胺化反应的新方法。2-嘧啶氧基苯和2-嘧啶基硫代苯，这可以很容易地从苯酚和硫酚，分别制备，然后由所得的嘧啶离子与哌啶处理的电化学氧化分别得到2-氨基苯并恶唑和2-氨基苯并噻唑。
A new method for metal-free intramolecular C-H amination has been developed. Electrochemical oxidation of 2-pyrimidyloxybenzenes and 2-pyrimidylthiobenzenes, which can be easily prepared from phenols and thiophenols, respectively, followed by the treatment of the resulting pyrimidinium ions with piperidine gives 2-aminobenzoxazoles and 2-aminobenzothiazoles, respectively.