Stabilization of poliovirus against heat inactivation.
Stabilization of poliovirus against heat inactivation.
复制标题
脊髓灰质炎病毒热灭活的稳定性。
DOI：
10.1016/0006-291x(89)92234-1
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
Klibanov,AM
中科院分区：
文献类型：
--
作者：
Dorval,BL;Chow,M;Klibanov,AM
Fatty acids and related compounds, as well as many salts, stabilize poliovirus against heat inactivation. Addition of myristate to poliovirus prevents heat-induced conformational changes which are detected by trypsin degradation of the virion. Using equilibrium dialysis, we found that several molecules of myristate bind per virion. The relative stabilizing potencies of the salts can be explained by the Hofmeister effect.
