Mechanisms of gene silencing by double-stranded RNA
Mechanisms of gene silencing by double-stranded RNA
复制标题
DOI：
10.1038/nature02873
复制
发表时间：
2004-09-16
期刊：
影响因子：
64.8
通讯作者：
Tuschl, T
中科院分区：
文献类型：
--
作者：
Meister, G;Tuschl, T
双链RNA （dsRNA）是许多真核生物基因表达的重要调控因子。它触发了不同类型的基因沉默，这些基因沉默统称为RNA沉默或RNA干扰。已知沉默途径的关键步骤是将dsrna加工成具有特征大小和结构的短RNA双链。这些短的dsrna通过特定和独特的机制引导RNA沉默。RNA沉默机制的许多组成部分仍需要识别和表征，但对这一过程的更全面了解迫在眉睫。
Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterized, but a more complete understanding of the process is imminent.