Eukaryotic DNA mismatch repair
Eukaryotic DNA mismatch repair
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DOI：
10.1016/s0959-437x(99)80013-6
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发表时间：
1999-02-01
影响因子：
4
通讯作者：
Marsischky, GT
中科院分区：
文献类型：
--
作者：
Kolodner, RD;Marsischky, GT
真核错配修复（MMR）已被证明需要两种不同的mts相关蛋白的异二聚体复合物：MSH2-MSH3和MSH2-MSH6。这两种复合物具有不同的错偶识别特性和不同的支持MMR的能力。关于这些MSH复合物如何在MMR中起作用，已经提出了其他模型。MLH1-PMS1（人PMS2）和MLH1-MLH3（人PMS1）也在MMR中起作用，并与其他MMR蛋白（包括MSH复合物和复制因子）相互作用。许多其他蛋白质与MMR有关，包括DNA聚合酶delta， RPA（复制蛋白A）， PCNA（增殖细胞核抗原），RFC（复制因子C），外切酶1，FEN1 （RAD27）以及DNA聚合酶delta和epsilon相关的外切酶。MMR蛋白也被证明在其他类型的修复和重组中起作用，这些修复和重组似乎与MMR不同。MMR蛋白在这些过程中与核苷酸切除修复（NER）和可能的重组组分一起起作用。
Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2-MSH3 and MSH2-MSH6. Those two complexes have different mispair recognition properties and different abilities to support MMR. Alternative models have been proposed for how these MSH complexes function in MMR. Two different heterodimeric complexes of MutL-related proteins, MLH1-PMS1 (human PMS2) and MLH1-MLH3 (human PMS1) also function in MMR and appear to interact with other MMR proteins including the MSH complexes and replication factors. A number of other proteins have been implicated in MMR, including DNA polymerase delta, RPA (replication protein A), PCNA (proliferating cell nuclear antigen), RFC (replication factor C), Exonuclease 1, FEN1 (RAD27) and the DNA polymerase delta and epsilon associated exonucleases. MMR proteins have also been shown to function in other types of repair and recombination that appear distinct from MMR. MMR proteins function in these processes in conjunction with components of nucleotide excision repair (NER) and, possibly, recombination.