The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models
The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models
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DOI：
10.1093/nar/gkh008
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Schwede, T
中科院分区：
文献类型：
--
作者：
Kopp, J;Schwede, T
SWISS-MODEL Repository是由全自动同源建模管道SWISS-MODEL生成的注释三维比较蛋白质结构模型的数据库。该库目前包含大约30万个来自SwissProt和TrEMBL数据库的序列三维模型。知识库的内容定期更新，纳入新的序列，利用新的模板结构，并反映基本建模算法的改进。每个条目包括一个或多个三维蛋白质模型、叠加的模板结构、模型所基于的比对、建模过程的总结和基于力场的质量评估。SWISS-MODEL储存库可通过互动网站http://swissmodel.expasy.org/repository/查询。模型与其他数据库的注释和交联，例如ExPASy服务器上的Swiss-Prot，允许蛋白质序列和结构信息之间的无缝导航。SWISS-MODEL Repository的目的是提供对由自动同源建模生成的注释的三维蛋白质模型的最新集合的访问，弥合序列和结构数据库之间的差距。
The SWISS-MODEL Repository is a database of annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline SWISS-MODEL. The Repository currently contains about 300 000 three-dimensional models for sequences from the SwissProt and TrEMBL databases. The content of the Repository is updated on a regular basis incorporating new sequences, taking advantage of new template structures becoming available and reflecting improvements in the underlying modelling algorithms. Each entry consists of one or more three-dimensional protein models, the superposed template structures, the alignments on which the models are based, a summary of the modelling process and a force field based quality assessment. The SWISS-MODEL Repository can be queried via an interactive website at http://swissmodel.expasy.org/repository/. Annotation and cross-linking of the models with other databases, e.g. Swiss-Prot on the ExPASy server, allow for seamless navigation between protein sequence and structure information. The aim of the SWISS-MODEL Repository is to provide access to an up-to-date collection of annotated three-dimensional protein models generated by automated homology modelling, bridging the gap between sequence and structure databases.