Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats
Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats
复制标题
不同剂量放疗对大鼠皮下肺泡包虫病的疗效
DOI：
10.3760/cma.j.issn.0366-6999.2011.18.009
复制
发表时间：
2011-09-20
影响因子：
6.1
通讯作者：
Bao Yong-xing
中科院分区：
文献类型：
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作者：
Zhang Yue-fen;Xie Zeng-ru;Bao Yong-xing
背景泡状棘球绦虫病(AE)是一种危害人类和动物的疾病，其治愈率并不令人满意。本研究旨在探讨不同剂量局部放射治疗大鼠泡状棘球绦虫病的疗效。方法将感染多房棘球绦虫的大鼠随机分为低、中、高3个剂量组和对照组，每组15只。对照组不作任何治疗，照射组大鼠分别接受6 MeV照射，剂量分别为20Gy8次、40Gy8次、60Gy8F3次，每3d 1次，共8次。放射治疗1个月后，检测各组大鼠的湿重和AE泡抑制率。对AE病变组织进行组织病理学和超微结构观察。结果治疗组对大鼠声发射有明显的抑制作用，抑制率分别为50%、72%和82%。皮损的病理改变和平均湿重与对照组相比也有统计学差异(P<；0.05)。治疗组AE包膜壁层和生发层超微结构均有不同程度的损伤，其中以高剂量组损伤最重。结论放射治疗对AE的生长有剂量依赖性的抑制作用。
Background Alveolar echinococcosis (AE) is a disease in human and animals, and the cure rate is unsatisfactory. This study aimed to investigate the curative efficacy of different doses of locally applied radiotherapy on alveolar echinococcosis in rats. Methods Rats infected with Echinococcus multilocularis were randomly divided into 4 groups of 15 rats each: low‐, middle‐, and high‐irradiation groups and a control group. Rats in the control group underwent no treatment, while rats in the irradiation groups received 6‐MeV radiotherapy at 20 Gy/8 f, 40 Gy/8 f, and 60 Gy/8 f respectively, once every 3 days for a total of 8 times. One month after radiotherapy, wet weight and AE vesicle inhibitory rate were detected in rats of each group. Histopathologic and ultrastructural observations of tissues with AE lesions were performed. Results In the treatment groups, an obvious inhibitory effect was found in AE rats; the inhibitory rates were 50%, 72%, and 82%, respectively. There were also statistical differences in pathological changes and average wet weight of the lesions compared with the control group (P <0.05). In the treatment groups, injuries of various degrees were found in the ultrastructure of the laminated and germinal layers in the capsular wall of AE, and injury was most severe in the high‐dose group. Conclusion Radiotherapy has a dose‐dependent inhibitory effect on the growth of AE.