Depressing synapse as a detector of frequency change
Depressing synapse as a detector of frequency change
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DOI：
10.1016/j.jtbi.2010.06.028
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发表时间：
2010-10-07
影响因子：
2
通讯作者：
Zygierewicz, Jaroslaw
中科院分区：
文献类型：
--
作者：
Jedrzejewska-Szmek, Joanna;Zygierewicz, Jaroslaw
在这篇文章中，我们讨论了短期突触抑制的数学模型。我们推导出无限短刺激时间的情况下，突触囊泡耗尽引起的突触抑制模型，并表明，突触后电位（PSP）和动力学函数的解析公式采取简单的封闭形式。这种形式的解决方案允许分析抑郁症的特征作为模型参数的函数，并推导出实验研究中常用的短时突触抑郁症的分析公式。这些公式被用来验证模型，通过拟合它的两种类型的突触在文献中描述。给定拟合的参数，我们讨论的突触的行为的情况下，涉及频率的变化。我们还指出了一个可能的作用，压抑的突触在信息处理中，不仅是一个过滤器的高频输入，但作为一个检测器的回报，从高频刺激到特定的频带内的刺激为一个给定的突触。(C)2010爱思唯尔有限公司保留所有权利。
In this article we discuss the short-term synaptic depression using a mathematical model. We derive the model of synaptic depression caused by the depletion of synaptic vesicles for the case of infinitely short stimulation time and show that the analytical formulas for the postsynaptic potential (PSP) and kinetic functions take simple closed form. A solution in this form allows an analysis of the characteristics of depression as a function of the models parameters and the derivation of analytic formulas for measures of short time synaptic depression commonly used in experimental studies. Those formulas are used to validate the model by fitting it to two types of synapses described in the literature. Given the fitted parameters we discuss the behavior of the synapse in situations involving frequency change. We also indicate a possible role of depressing synapses in information processing as not only a filter of high frequency input but as a detector of the return from high frequency stimulation to the stimulation within frequency band specific for a given synapse. (C) 2010 Elsevier Ltd. All rights reserved.