Hemodynamic, ventilatory, and biochemical responses of panic patients and normal controls with sodium lactate infusion and spontaneous panic attacks.
Hemodynamic, ventilatory, and biochemical responses of panic patients and normal controls with sodium lactate infusion and spontaneous panic attacks.
复制标题
惊恐患者和正常对照者对乳酸钠输注和自发惊恐发作的血流动力学、通气和生化反应。
作者：
F. Gaffney;B. Fenton;L. D. Lane;C. Lake
对10名健康成人和10名惊恐患者在输注0.5mol/L乳酸钠期间的血流动力学、呼吸动力学和生化指标进行了测定。体力活动、健康水平和动态心电图也被记录下来。乳酸盐输注使心输出量加倍，血乳酸水平增加6倍，并产生高钠血症、低钙血症，两组血清碳酸氢盐水平降低，但仅患者动脉压升高。患者在输注前和输注期间过度通气。生理反应和躯体投诉与输液组之间的差异不大，但情绪投诉是6倍更频繁的恐慌患者。八名患者，但没有控制对象解释他们的症状为恐慌发作。31例记录的自发性门诊恐慌发作中只有14例心率增加。乳酸钠输注似乎通过模仿自发性恐慌的生理学而产生恐慌。在没有心肺或自主神经系统异常的情况下，不适用心脏活性药物治疗。
Hemodynamic, ventilatory, and biochemical variables were measured in ten healthy adults and ten panic patients during infusion of 0.5 mol/L of sodium lactate. Physical activity, fitness level, and ambulatory electrocardiograms were also recorded. Lactate infusion doubled cardiac output, increased blood lactate levels by sixfold, and produced hypernatremia, hypocalcemia, and decreased serum bicarbonate levels in both groups but raised arterial pressure only in the patients. The patients hyperventilated before and during the infusion. Physiological responses and somatic complaints with the infusion differed little between the groups, but emotional complaints were six times more frequent among the panic patients. Eight patients but no control subjects interpreted their symptoms as a panic attack. Heart rate increased with only 14 of 31 recorded spontaneous outpatient panic attacks. Sodium lactate infusions appear to produce panic by mimicking the physiology of spontaneous panic. Treatment with cardioactive agents is not indicated in the absence of cardiopulmonary or autonomic nervous system abnormalities.
影响因子：
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作者：
D. Charney;G. Heninger;A. Breier
通讯作者：
D. Charney;G. Heninger;A. Breier
一组惊恐障碍患者对过度换气的反应。
DOI：
10.1176/ajp.141.7.857
发表时间：
1984
期刊：
The American journal of psychiatry
影响因子：
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作者：
Gorman,JM;Askanazi,J;Liebowitz,MR;Fyer,AJ;Stein,J;Kinney,JM;Klein,DF
通讯作者：
Klein,DF
咖啡因在惊恐障碍中增加焦虑作用。
影响因子：
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作者：
Charney,DS;Heninger,GR;Jatlow,PI
通讯作者：
Jatlow,PI