Asthma and Sinusitis: Association and Implication
Asthma and Sinusitis: Association and Implication
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哮喘和鼻窦炎：关联和影响
DOI：
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发表时间：
2008
影响因子：
2.8
通讯作者：
T. Kumamoto
中科院分区：
文献类型：
--
作者：
O. Matsuno;E. Ono;Ryuichi Takenaka;Toshiyuki Okubo;K. Takatani;T. Ueno;Takahiro Nishitake;Shigeo Hiroshige;T. Sawabe;Tetsurou Matsumoto;E. Miyazaki;T. Kumamoto
背景：鼻窦炎是哮喘患者的常见病。鼻窦炎和下气道疾病的流行病学资料必须谨慎评估，因为它们主要基于症状，而不包括鼻内窥镜或计算机断层扫描（CT）的发现。缺乏这种关联的临床支持和证据。我们评估了鼻窦炎对哮喘患者下气道疾病的影响。方法：研究对象（n = 188）完成了一份问卷，旨在提供他们与哮喘、过敏性鼻炎（AR）和鼻窦疾病相关的体征和症状信息。根据鼻窦炎和/或AR的存在与否将患者（n = 104）分为四组。由耳鼻喉科医生或鼻窦CT检查比较有鼻窦炎和没有鼻窦炎的哮喘患者的临床表现。结果：哮喘患者鼻窦炎患病率为36.7%。66.3%的哮喘患者鼻窦CT扫描异常。在没有鼻窦炎病史的哮喘患者中，17.9%的患者扫描显示异常混浊。有鼻窦炎和无鼻窦炎患者的哮喘严重程度与鼻窦形态异常有显著相关性。在成人发病哮喘（≥16岁）中，鼻窦炎常先于哮喘，而在非成人发病哮喘（<16岁）中，鼻窦炎常先于哮喘。成人哮喘患者鼻窦炎并发症发生率明显高于非成人哮喘患者。结论：支气管哮喘与鼻窦炎密切相关，哮喘发病年龄是考虑变应性疾病发病频率的重要因素。鼻窦疾病是否直接影响支气管炎症的强度仍有待阐明。
Background: Sinusitis occurs frequently in asthmatic patients. Epidemiologic data on sinusitis and lower airway disease must be evaluated with caution because they are based mostly on symptoms and do not include nasal endoscopic or computed tomography (CT) findings. Clinical support and evidence for this association are lacking. We evaluated the impact of sinusitis on lower airway disease in patients with well-characterized asthma. Methods: Subjects (n = 188) completed a questionnaire designed to provide information about their signs and symptoms related to asthma, allergic rhinitis (AR) and sinus disease. Patients (n = 104) were divided into four groups based on the presence or absence of sinusitis and/or AR. Clinical findings were compared in asthma patients with and without diagnosed sinusitis, by an otorhinolaryngologist or based on sinus CT findings. Results: The prevalence of sinusitis in patients with asthma was 36.7%. Sinus CT scan abnormalities were detected in 66.3% of patients with asthma. The scans revealed abnormal opacity in 17.9% of asthmatic patients without a history of sinusitis. There was a significant correlation between the rate of asthma severity and sinus morphologic abnormalities in patients with and without sinusitis. In adult-onset asthma (≧16 years old), sinusitis frequently preceded asthma, whereas in non-adult-onset asthma (<16 years old) it preceded sinusitis. The complication rate of sinusitis in asthmatic patients was significantly higher in adult-onset asthma than in non-adult-onset asthma. Conclusions: Our findings suggest that bronchial asthma is closely related to sinusitis and the onset age of asthma is important when considering allergic disease frequency. Whether sinus disease directly affects the intensity of bronchial inflammation remains to be elucidated.
影响因子：
120.7
作者：
NEWMAN, LJ;PLATTSMILLS, TAE;GROSS, CW
通讯作者：
GROSS, CW
影响因子：
14.2
作者：
Guerra, S;Sherrill, DL;Barbee, RA
通讯作者：
Barbee, RA