Oesophageal cancer survival in Europe: A EUROCARE-4 study
Oesophageal cancer survival in Europe: A EUROCARE-4 study
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DOI：
10.1016/j.canep.2012.07.009
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发表时间：
2012-12-01
影响因子：
2.6
通讯作者：
Anderson, L. A.
中科院分区：
文献类型：
--
作者：
Gavin, A. T.;Francisci, S.;Anderson, L. A.
欧洲各地的食管癌生存率较低且存在差异。目前还没有关于食管癌亚型生存差异的泛欧洲研究。这项研究调查了整个欧洲食道癌的生存率和趋势。从 24 个欧洲国家的 66 个癌症登记处获取了 1995 年至 1999 年诊断的原发性恶性食管癌以及截至 2003 年底的随访数据。使用 Hakulinen 方法计算相对生存率。分期数据可从 19 个登记处获得。按地区、性别、年龄、形态和阶段对存活率进行了调查。采用队列分析和时期方法来调查 17 个国家 31 个登记处 1988 年至 2002 年的生存趋势。对 1995 年至 1999 年诊断的总共 51,499 例食道癌病例进行了分析。总体而言，欧洲 1 年和 5 年生存率分别为 33.4%（95% CI 32.9-33.9%）和 9.8%（95% CI 9.4-10.1%）。男性、老年患者和晚期疾病患者的 1 年和 5 年相对生存率较差。鳞状细胞癌患者的 1 年相对生存率较差。观察到生存率存在区域差异，中欧高于欧洲群体，东欧低于欧洲群体。整个欧洲的远期疾病生存率相似，而东欧和南欧的局部疾病生存率低于欧洲群体。据报道，欧洲 1 年相对生存率有所改善 (p = 0.016)。整个欧洲的食道癌生存率都很低。一年生存率持续存在的区域差异表明需要对食管癌的诊断和治疗实践进行高分辨率研究。 (C) 2012 Elsevier Ltd. 保留所有权利。
Oesophageal cancer survival is poor with variation across Europe. No pan-European studies of survival differences by oesophageal cancer subtype exist. This study investigates rates and trends in oesophageal cancer survival across Europe. Data for primary malignant oesophageal cancer diagnosed in 1995-1999 and followed up to the end of 2003 was obtained from 66 cancer registries in 24 European countries. Relative survival was calculated using the Hakulinen approach. Staging data were available from 19 registries. Survival by region, gender, age, morphology and stage was investigated. Cohort analysis and the period approach were applied to investigate survival trends from 1988 to 2002 for 31 registries in 17 countries. In total 51,499 cases of oesophageal cancer diagnosed 1995-1999 were analysed. Overall, European 1- and 5-year survival rates were 33.4% (95% CI 32.9-33.9%) and 9.8% (95% CI 9.4-10.1%), respectively. Males, older patients and patients with late stage disease had poorer 1- and 5-year relative survival. Patients with squamous cell carcinoma had poorer 1-year relative survival. Regional variation in survival was observed with Central Europe above and Eastern Europe below the European pool. Survival for distant stage disease was similar across Europe while survival rates for localised disease were below the European pool in Eastern and Southern Europe. Improvement in European 1-year relative survival was reported (p = 0.016). Oesophageal cancer survival was poor across Europe. Persistent regional variations in 1-year survival point to a need for a high resolution study of diagnostic and treatment practices of oesophageal cancer. (C) 2012 Elsevier Ltd. All rights reserved.