Comorbidity between patterns of substance use dependence and psychiatric syndromes
Comorbidity between patterns of substance use dependence and psychiatric syndromes
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DOI：
10.1016/s0376-8716(01)00126-0
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发表时间：
2001-10-01
影响因子：
4.2
通讯作者：
Davies, M
中科院分区：
文献类型：
--
作者：
Kandel, DB;Huang, FY;Davies, M
背景资料：在全国药物滥用家庭调查（NHSDA）的全国样本中检查了对单一和多种药物的依赖与精神综合征的共病性。方法：受试者是1994年，1995年和1996年NHSDA调查的成年人。在过去的一年中，药物依赖的代理措施，从五个依赖症状，近似DSM-IV标准。同时依赖于香烟，酒精和非法药物的模式的措施。严重抑郁发作和任何焦虑症（广泛性焦虑症，广场恐怖症和惊恐发作）的错误指标是基于过去一年内测量症状的量表。通过调整后的比值比估计合并症。结果：可能药物依赖者精神症状发生率较高。精神病综合征的发生率与那些仅依赖酒精、香烟或非法药物的患者相似（调整后的比值比约为2.0）。同时依赖非法药物和合法药物的人的死亡率几乎翻了一番。结论：单独依赖于单一药物类别的个体的精神病发病率相似。所有依赖非法药物的人患精神病综合症的比率都较高。这反映了对法律的和非法药物的依赖与精神障碍的叠加关系，以及在依赖非法药物的人中对法律的药物的依赖率增加。对法律的和非法药物有多重依赖的人对心理健康服务的需求最高。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Background: Comorbidity of dependence on single and multiple drugs with psychiatric syndromes was examined in national samples from the National Household Survey on Drug Abuse (NHSDA). Methods: Subjects are adults from the 1994, 1995 and 1996 NHSDA surveys. Proxy measures of drug dependence in the last year were constructed from five dependence symptoms that approximated DSM-IV criteria. Measures of patterns of concurrent dependence on cigarettes, alcohol and illicit drugs were constructed. Fallible indicators of a major depressive episode and any anxiety disorder (generalized anxiety disorder, agoraphobia and panic attack) were based on scales measuring symptoms during the last: year. Comorbidity was estimated by adjusted odds ratios. Results: Probable drug dependent individuals have higher rates of psychiatric syndromes. Rates of psychiatric syndromes were similar for those uniquely dependent on alcohol, cigarettes or illicit drugs (adjusted odds ratios approximate to 2.0). Rates almost doubled for those dependent on both an illicit and a licit drug. Conclusions: Individuals uniquely dependent on a single drug class experience similar rates of psychiatric morbidity. All those dependent on illicit drugs experience higher rates of psychiatric syndromes. This reflects the additive association of dependence on legal and illegal drugs with psychiatric disorders and the increased rates of dependence on a legal drug among those dependent on an illicit drug. Individuals with multiple dependencies on legal and illegal drugs have the highest need for mental health services. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.