Age-related maculopathy in a multiracial United States population - The national health and nutrition examination survey III
Age-related maculopathy in a multiracial United States population - The national health and nutrition examination survey III
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DOI：
10.1016/s0161-6420(99)90255-5
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发表时间：
1999-06-01
期刊：
影响因子：
13.7
通讯作者：
Palta, M
中科院分区：
文献类型：
--
作者：
Klein, R;Klein, BEK;Palta, M
目的：调查年龄相关性黄斑病变（ARM）的患病率和危险因素在三个种族/民族：非西班牙裔白人，非西班牙裔黑人，墨西哥裔American.Design：一个全国代表性的人口为基础的，横断面研究。参会人员：共8270人40岁或以上，第三次全国健康与营养检查Survey.Main Outcome Measures的样本：视网膜相关性黄斑病变通过眼底照片分级使用标准化协议确定。在美国非住院的平民人群中，包括40岁或以上的人群，任何ARM的患病率为9.4%。（95%置信区间[CI]，8.2，10.6）。在调整年龄后，不同种族/种族组的早期ARM（主要由软玻璃疣的存在定义）的患病率没有差异。然而，对于早期ARM的不太常见的成分病变，（视网膜色素增加和视网膜色素上皮脱失），非西班牙裔黑人与非西班牙裔白人相比的比值比（95%Cls）为0.47（0.31，0.74）和0.59（0.33，1.04），而墨西哥裔美国人与非西班牙裔白人相比，分别为0.41（0.21，0.81）和0.72（0.44，1.19）。对于晚期ARM，非西班牙裔黑人与非西班牙裔白人相比的比值比（95%CI）为0.34（0.10，1.18），墨西哥裔美国人与非西班牙裔白人相比的比值比为0.25（0.07，0.90）。除了年龄，没有个人，医疗，或生理变量的研究与任何的ARM端点在任何三个种族/ethnic groups.Conclusion：总体而言，任何ARM（包括所有早期和晚期病变）的比率没有显着差异之间的非西班牙裔黑人，墨西哥裔美国人，和非西班牙裔白人。然而，个别病变的发生率表明，非西班牙裔白人和墨西哥裔美国人可能会受到保护，防止视网膜色素异常和病变与晚期ARM. There相关的个人，医疗和环境因素的影响不大，这些结果的研究。对这些族裔群体中更多老年人的进一步研究可能会澄清这些关系。
Objective: To investigate the prevalence of and risk factors for age-related maculopathy (ARM) in three racial/ethnic groups: non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans.Design: A nationally representative population-based, cross-sectional study. Participants: A total of 8270 persons 40 years of age or older, a sample of the Third National Health and Nutrition Examination Survey.Main Outcome Measures: Age-related maculopathy was determined by the grading of fundus photographs using a standardized protocol.Results: The prevalence of any ARM in the civilian noninstitutionalized United States population including those 40 years of age or older was 9.4% (95% confidence interval [CI], 8.2, 10.6) as estimated from the sample. After adjusting for age, there was no difference in the prevalence of early ARM (defined largely by the presence of soft drusen) by ethnic/racial group. However, for the less frequent component lesions of early ARM (increased retinal pigment and retinal pigment epithelial depigmentation), the odds ratios (95% Cls) comparing non-Hispanic blacks to non-Hispanic whites were 0.47 (0.31, 0.74) and 0.59 (0.33, 1.04), respectively, and for comparing Mexican-Americans to non-Hispanic whites, they were 0.41 (0.21, 0.81) and 0.72 (0.44, 1.19), respectively. For late ARM, the odds ratio (95% CI) for non-Hispanic blacks compared to non-Hispanic whites was 0.34 (0.10, 1.18) and for Mexican-Americans compared to non-Hispanic whites, it was 0.25 (0.07, 0.90). Other than age, none of the personal, medical, or physiologic variables studied were statistically significantly associated with any of the ARM endpoints in any of the three races/ethnic groups.Conclusion: Overall, rates of any ARM (including all early and late lesions) ave not significantly different among non-Hispanic blacks, Mexican-Americans, and non-Hispanic whites. However, the rates of individual lesions suggest that non-Hispanic whites and Mexican-Americans may be protected against retinal pigment abnormalities and lesions associated with late ARM. There appears to be little influence of personal, medical, and environmental factors studied on these results. Further studies in larger populations of older persons in these ethnic groups would likely clarify these relations.