Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
复制标题
Ro-07-0582的细胞毒性；
作者：
E. Hall;M. Astor;C. Geard;J. Biaglow
Ro-07-0582 对缺氧细胞表现出的选择性细胞毒性强烈依赖于温度。这种细胞毒性被自由基清除剂半胱胺降低，表明硝基自由基或亚硝基中间体参与了药物的细胞杀伤作用。即使存活分数减少到 0-01，Ro-07-0582 也不会诱导染色体畸变。
The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.