An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
复制标题
Sirtuins 作为潜在治疗靶点的概述：结构、功能和调节剂
DOI：
10.1016/j.ejmech.2018.10.028
复制
发表时间：
2019
影响因子：
6.7
通讯作者：
Ouyang Liang
中科院分区：
文献类型：
--
作者：
Wang Yijie;He Jun;Liao Mengya;Hu Mingxing;Li Wenzhen;Ouyang Hongling;Wang Xin;Ye Tinghong;Zhang Yiwen;Ouyang Liang
Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.
