Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders
Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders
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DOI：
10.1136/oem.2006.028761
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发表时间：
2007-03-01
影响因子：
4.9
通讯作者：
Doty, Richard L.
中科院分区：
文献类型：
--
作者：
Bowler, Rosemarie M.;Roels, Harry A.;Doty, Richard L.
工作背景：虽然在采矿、矿石加工和铁合金生产中接触高锰（Mn）的工人中对神经心理和神经健康的不良影响是众所周知的，但对接触较低锰的焊工的风险了解较少。采用多学科方法研究了旧金山-奥克兰海湾大桥新跨施工中无足够保护的受限空间焊接，有害健康效应与空气或全血中锰的效应关系。桥焊工（n = 43）很少或没有个人防护设备，并暴露于含锰的焊接烟雾，进行神经，神经心理，神经生理和肺测试。结果变量进行了分析，全血锰（MnB）和累积暴露指数（CEI）的基础上锰-空气，持续时间和类型的焊接。结果：焊接工人平均焊接时间为16.5个月，平均年龄43.8岁，平均受教育年限12.6年。锰B> 10 μ g/l者占43%，尿锰、血铅、血浆铜、铁均正常。1 s用力呼气容积：用力肺活量比值（FEV 1/FVC）在焊接工人1.5年后有33.3%的人出现异常。运动迟缓和统一帕金森病评定量表的平均得分分别超过4和6。计算机辅助震颤分析系统的手震颤和身体摇摆测试，宾夕法尼亚大学识别测试显示，38.5/61.5，51.4和88%的焊工，分别损害。发现与CEI和/或MnB呈显著的剂量-效应反比关系的IQ（p
Background: Although adverse neuropsychological and neurological health effects are well known among workers with high manganese (Mn) exposures in mining, ore-processing and ferroalloy production, the risks among welders with lower exposures are less well understood.Methods: Confined space welding in construction of a new span of the San Francisco-Oakland Bay Bridge without adequate protection was studied using a multidisciplinary method to identify the dose-effect relationship between adverse health effects and Mn in air or whole blood. Bridge welders (n = 43) with little or no personal protection equipment and exposed to a welding fume containing Mn, were administered neurological, neuropsychological, neurophysiological and pulmonary tests. Outcome variables were analysed in relation to whole blood Mn (MnB) and a Cumulative Exposure Index (CEI) based on Mn-air, duration and type of welding. Welders performed a mean of 16.5 months of welding on the bridge, were on average 43.8 years of age and had on average 12.6 years of education.Results: The mean time weighted average of Mn-air ranged from 0.11-0.46 mg/m(3) (55% > 0.20 mg/m(3)). MnB > 10 mu g/l was found in 43% of the workers, but the concentrations of Mn in urine, lead in blood and copper and iron in plasma were normal. Forced expiratory volume at 1s: forced vital capacity ratios (FEV1/FVC) were found to be abnormal in 33.3% of the welders after about 1.5 years of welding at the bridge. Mean scores of bradykinesia and Unified Parkinson Disease Rating Scale exceeded 4 and 6, respectively. Computer assisted tremor analysis system hand tremor and body sway tests, and University of Pennsylvania Smell Identification Test showed impairment in 38.5/61.5, 51.4 and 88% of the welders, respectively. Significant inverse dose-effect relationships with CEI and/or MnB were found for IQ (p