Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.
Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.
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DOI：
10.1039/d1sm00839k
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发表时间：
2021-09-15
期刊：
影响因子：
3.4
通讯作者：
Laverty G
中科院分区：
文献类型：
--
作者：
Cross ER;Coulter SM;Pentlavalli S;Laverty G
水凝胶作为抗感染应用的生物材料和药物递送平台的使用已经引起了极大的兴趣。几十年来，抗微生物肽一直被认为是一种急需的新型抗微生物药物。具有内在抗菌能力的自组装肽水凝胶最近脱颖而出。然而，它们的基本抗菌特性、选择性和作用机制相对不明确。本文通过对几种已报道的肽系统（β-发夹/β-环肽、多结构域肽、两亲性表面活性剂样肽和超短/低分子量肽）的研究，试图建立抗菌功效、自组装过程、肽-膜相互作用和机械性能之间的联系。我们还探讨了它们在淀粉样斑块形成中的作用以及在阿尔茨海默病等疾病中感染病因的可能性。我们简要介绍了凝胶表征的创新方法。这些可能会提供有用的工具，为未来的研究在这个日益重要的领域。水凝胶作为抗感染应用的生物材料和药物递送平台的使用已经引起了极大的兴趣。
The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling peptide hydrogels with inherent antimicrobial ability have recently come to the fore. However, their fundamental antimicrobial properties, selectivity and mechanism of action are relatively undefined. This review attempts to establish a link between antimicrobial efficacy; the self-assembly process; peptide–membrane interactions and mechanical properties by studying several reported peptide systems: β-hairpin/β-loop peptides; multidomain peptides; amphiphilic surfactant-like peptides and ultrashort/low molecular weight peptides. We also explore their role in the formation of amyloid plaques and the potential for an infection etiology in diseases such as Alzheimer's. We look briefly at innovative methods of gel characterization. These may provide useful tools for future studies within this increasingly important field. The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications.