Comparison between the pathology of encapsulating sclerosis and simple sclerosis of the peritoneal membrane in chronic peritoneal dialysis
Comparison between the pathology of encapsulating sclerosis and simple sclerosis of the peritoneal membrane in chronic peritoneal dialysis
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DOI：
10.1111/j.1744-9987.2007.00538.x
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发表时间：
2008-02-01
影响因子：
1.9
通讯作者：
Nakayama, Masaaki
中科院分区：
文献类型：
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作者：
Sherif, Ali M.;Yoshida, Hiraku;Nakayama, Masaaki
分析包封性腹膜硬化（EPS）和单纯性腹膜硬化（非EPS）的组织病理学差异以及比较早期和晚期EPS病理差异的报告有限。我们提出了EPS和非EPS之间的病理比较，以及早期和晚期EPS之间的病理比较。我们比较了12例EPS患者（A组）和23例非EPS患者的腹膜（PM）样本（13组）：间皮丢失，亚间皮致密带退化层和致密带厚度，总血管和病变血管密度，纤维蛋白染色，新膜形成和退行性改变。A组分为早期EPS 7例（A1组）和晚期EPS 8例（A2组）；我们以同样的方式比较两个亚组，最后比较a1、A2和B组。A组和B组在间皮脱离、新膜形成和致密带退行性改变的发生率方面没有差异。致密区厚度和不同血管等级致密区血管密度均无差异。A组间皮下变性层纤维蛋白沉积和厚度显著高于B组（P = 0.01和0.05），致密区厚度显著低于A2组（P = 0.03）。纤维蛋白阳性染色和厚的退行性致密带层是EPS的重要病理表现。血管生成、血管病变、新膜形成、纤维化和致密区退行性改变并不是EPS独有的特征。建议进行更大规模的研究来验证这一问题。
Reports analyzing the histopathological differences between encapsulating peritoneal sclerosis (EPS) and simple peritonea) sclerosis (non-EPS) and those comparing the pathology of early and late EPS are limited. We present pathological comparisons between EPS and non-EPS, also between the earl), and late EPS stages. We compared peritoneal membrane (PM) samples (Group 13) of 12 EPS patients (Group A) and 23 non-EPS cases regarding; mesothelial loss, subi-nesothelial compact zone degenerated layer and compact zone thicknesses, densities of total and diseased vessels, fibrin stain, new membrane formation and degenerative changes. Group A was subdivided into 7 early (group A1) and 8 late (group A2) EPS cases; we compared both subgroups in the same manner and finally compared groups A 1, A2,and B. No differences were found between groups A and B in the incidences of mesothelial detachment, new membrane formation and compact zone degenerative changes between the two groups. Furthermore, there were no differences in compact zone thickness, and vascular densities in the compact zone of respective vascular grade. Whereas, fibrin deposition and thickness of the submesothelial degenerated layer were significantly higher in group A than group B (P = 0.01 and 0.05, respectively), and the thickness of the compact zone was less in group A1 than in group A2 (P = 0.03). Positive fibrin stains and thick degenerative compact zone layers are important pathological findings in EPS. Angiogenesis, vasculopathy, new membrane formation, fibrosis and degenerative changes of the compact zone are not unique characteristics for EPS. Larger size studies are recommended to verify this issue.