Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease.
Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease.
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感染 1 型人类免疫缺陷病毒的患者，即使患有牙周病，唾液中的病毒含量也较低。
DOI：
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发表时间：
1993
影响因子：
6.4
通讯作者：
Anthony L. Cunningham
中科院分区：
文献类型：
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作者：
Stephen Yeung;Farhad Kazazi;Christine G. M. Randle;Rebecca C. Howard;Nilofar Rizvi;Jean C Downie;Basil Donovan;David A. Cooper;Hiromasa Sekine;Dominic E. Dwyer;Anthony L. Cunningham
在两项连续研究中，对80例人类免疫缺陷病毒（HIV）-1血清阳性受试者（21例无症状，6例持续性全身淋巴结病，13例AIDS相关综合征和40例AIDS）进行了口腔病变检查。配对血清和唾液标本进行HIV分离、DNA和抗原检测。31例患者血清中检测到HIV抗原，但唾液中未检测到。从83%的血液单核细胞和21%的唾液上清液中分离出HIV。在第二项对25名患者的研究中，在血浆中检测到56%的HIV（滴度，1/10至> 1/1000），但在稀释的唾液上清液中没有检测到，即使在那些患有严重牙周病的患者中也是如此。用聚合酶链反应在7个唾液细胞团中的2个和5个血液样品中的4个中检测到HIV DNA。因此，在艾滋病毒感染的所有阶段，分别在21%和28%的艾滋病毒血清阳性患者中发现感染性艾滋病毒和DNA的浓度非常低。
In two consecutive studies, 80 subjects human immunodeficiency virus (HIV)-1-seropositive (21 asymptomatic, 6 persistent generalized lymphadenopathy, 13 AIDS-related complex, and 40 AIDS) were examined for oral lesions. Paired serum and saliva specimens were tested for HIV isolation, DNA, and antigen. HIV antigen was detected in sera from 31 patients, but not in saliva. HIV was isolated from blood mononuclear cells of 83% and saliva supernatants of 21%. In the second study of 25 patients, HIV was detected in plasma of 56% (titers, 1/10 to > 1/1000) but not in diluted saliva supernatants, even in those with severe periodontal disease. HIV DNA was detected using polymerase chain reaction in 2 of 7 saliva cell pellets and 4 of 5 blood samples. Hence, infectious HIV and DNA was found at very low concentrations in 21% and 28% of HIV-seropositive patients, respectively, at all stages of HIV infection.
影响因子：
158.5
作者：
DAAR, ES;MOUDGIL, T;HO, DD
通讯作者：
HO, DD