Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice.
Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice.
复制标题
小鼠中枢和全身注射血清素前体 5-羟色氨酸后的血清瘦素水平。
DOI：
10.1016/s0014-2999(00)00624-5
复制
发表时间：
2000
影响因子：
5
通讯作者：
Y. Sugimoto
中科院分区：
文献类型：
--
作者：
J. Yamada;M. Ujikawa;Y. Sugimoto
Effects of peripheral and central injections of a serotonin (5-hydroxytryptamine, 5-HT) precursor, 5-hydroxytryptophan (5-HTP), on serum leptin levels were studied in mice. Intracerebroventricular (i.c.v.) injection of 5-HTP or 5-HT did not increase serum leptin levels, although the peripheral injection of 5-HTP elicited an apparent hyperleptinemia. The elevation of serum leptin levels in mice induced by the peripheral injection of 5-HTP was inhibited by pretreatment with the peripheral aromatic amino acid decarboxylase inhibitor, benserazide. Furthermore, the peripheral injection of 5-HT increased serum leptin levels. These results suggest that the hyperleptinemia following systemic injection of 5-HTP is elicited by 5-HT formed in the peripheral system.
影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG