Molecular markers in glioma.
Molecular markers in glioma.
复制标题
胶质瘤中的分子标记。
DOI：
10.1007/s11060-017-2379-y
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发表时间：
2017-09
影响因子：
3.9
通讯作者：
Kornblum HI
中科院分区：
文献类型：
--
作者：
Ludwig K;Kornblum HI
Gliomas are the most malignant and aggressive form of brain tumors, and account for the majority of brain cancer related deaths. Malignant gliomas, including glioblastoma are treated with radiation and temozolomide, with only a minor benefit in survival time. A number of advances have been made in understanding glioma biology, including the discovery of cancer stem cells, termed glioma stem cells (GSC). Some of these advances include the delineation of molecular hetereogeneity both between tumors from different patients as well as within tumors from the same patient. Such research highlights the importance of identifying and validating molecular markers in glioma. This review, intended as a practical resource for both clinical and basic investigators, summarizes some of the more well-known molecular markers (MGMT, 1p/19q, IDH, EGFR, p53, PI3K, Rb, and RAF), discusses how they are identified, and what, if any, clinical relevance they many have, in addition to discussing some of the specific biology for these markers. Additionally, we discuss identification methods for studying putative GSC’s (CD133, CD15, A2B5, Nestin, ALDH1, Proteasome activity, ABC transporters, and Label-retention). While much research has been done on these markers, there is still a significant amount that we do not yet understand, which may account for some conflicting reports in the literature. Furthermore, it is unlikely that the investigator will be able to utilize one single marker to prospectively identify and isolate GSC from all, or possibly, any gliomas.
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影响因子：
37.3
作者：
Beier D;Schulz JB;Beier CP
通讯作者：
Beier CP
影响因子：
8
作者：
Jones DT;Kocialkowski S;Liu L;Pearson DM;Ichimura K;Collins VP
通讯作者：
Collins VP
影响因子：
15.9
作者：
Ichimura K;Pearson DM;Kocialkowski S;Bäcklund LM;Chan R;Jones DT;Collins VP
通讯作者：
Collins VP
影响因子：
8.8
作者：
Auvergne RM;Sim FJ;Wang S;Chandler-Militello D;Burch J;Al Fanek Y;Davis D;Benraiss A;Walter K;Achanta P;Johnson M;Quinones-Hinojosa A;Natesan S;Ford HL;Goldman SA
通讯作者：
Goldman SA
DOI：
10.1007/978-3-319-12048-5_2
发表时间：
2015-01-01
期刊：
CURRENT UNDERSTANDING AND TREATMENT OF GLIOMAS
影响因子：
--
作者：
Cohen, Adam L.;Colman, Howard
通讯作者：
Colman, Howard