Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila
Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila
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DOI：
10.1016/j.neuron.2017.10.030
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发表时间：
2017-12-20
期刊：
影响因子：
16.2
通讯作者：
Nose, Akinao
中科院分区：
文献类型：
--
作者：
Takagi, Suguru;Cocanougher, Benjamin Thomas;Nose, Akinao
动物对触觉刺激的适应性反应是根据刺激的位置选择与动物行为学相关的行为。在这里，我们研究了果蝇幼虫不同身体部位的体感输入如何与不同的运动输出相关联。当触碰头部时，幼虫会向后移动，而当触碰尾部时，它们会向前爬行。我们确定了一类节段重复的二级体感觉中间神经元，我们将其命名为Wave，其在前节和后节的激活分别引起向后和向前运动。前波神经元和后波神经元的树突向相反方向延伸，分别接收来自头部和尾部的体感信号。在前波神经元的下游，我们确定了包括神经元A03a5在内的前运动回路，它与波一起是向后运动触摸反应所必需的。因此，波神经元通过参与不同节段的不同回路，将它们的接受野与适当的运动程序相匹配。
Animals adaptively respond to a tactile stimulus by choosing an ethologically relevant behavior depending on the location of the stimuli. Here, we investigate how somatosensory inputs on different body segments are linked to distinct motor outputs in Drosophila larvae. Larvae escape by backward locomotion when touched on the head, while they crawl forward when touched on the tail. We identify a class of segmentally repeated second-order somatosensory interneurons, that we named Wave, whose activation in anterior and posterior segments elicit backward and forward locomotion, respectively. Anterior and posterior Wave neurons extend their dendrites in opposite directions to receive somatosensory inputs from the head and tail, respectively. Downstream of anterior Wave neurons, we identify premotor circuits including the neuron A03a5, which together with Wave, is necessary for the backward locomotion touch response. Thus, Wave neurons match their receptive field to appropriate motor programs by participating in different circuits in different segments.