Killing of Enterococcus faecalis by MTAD and Chlorhexidine Digluconate with or without Cetrimide in the Presence or Absence of Dentine Powder or BSA
Killing of Enterococcus faecalis by MTAD and Chlorhexidine Digluconate with or without Cetrimide in the Presence or Absence of Dentine Powder or BSA
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DOI：
10.1016/j.joen.2005.10.027
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发表时间：
2006-02-01
影响因子：
4.2
通讯作者：
Haapasalo, Markus
中科院分区：
文献类型：
--
作者：
Portenier, Isabelle;Waltimo, Tuomas;Haapasalo, Markus
根管冲洗液和局部消毒剂的体内抗菌效果不如体外抗菌效果。一种解释可能是由于根管中存在的化合物而失活。美托洛尔（四环素异构体、酸和清洁剂的混合物）是一种新型的具有抗菌活性的根管冲洗液。本研究的目的是研究美托洛尔和洗必泰对两株粪肠球菌的抗菌活性以及牙本质和牛血清白蛋白对抗菌活性的抑制作用。在体外模型中监测在存在或不存在抑制剂的情况下暴露于药物的细菌的存活。全浓度（100%）的甲氨蝶呤和0.2%的洗必泰迅速杀死这两种菌株。氯己定与西曲溴铵的组合进一步减少了杀灭所需的时间。牙本质或BSA的存在引起两种药物的杀死的显著延迟。两个E。测试的粪菌菌株对消毒剂的敏感性略有不同。（J Endod 2006;32：138-141）
The antibacterial efficacy of irrigating solutions and local disinfectants used in endodontics appears poorer in vivo than in vitro. One explanation may be inactivation by compounds present in the root canal. MTAD (a mixture of tetracycline isomer, acid, and detergent) is a new root canal irrigation solution with antibacterial activity. The aim of this study was to investigate the antibacterial activity of MTAD and chlorhexidine towards two strains of Enterococcus faecalis and the inhibitory effects of dentine and bovine serum albumin on the antibacterial activity. Survival of bacteria exposed to the medicaments in the presence or absence of inhibitors was monitored in an in vitro model. Full concentration (100%) MTAD and 0.2% chlorhexidine rapidly killed both strains. Combining chlorhexidine with cetrimide further reduced the time required for killing. The presence of dentine or BSA caused a marked delay in killing by both medicaments. The two E. faecalis strains tested showed minor differences in their susceptibility to the disinfectants. (J Endod 2006;32:138-141)