Effect of Low Dose Vitamin K2 (MK-4) Supplementation on Bio-Indices in Postmenopausal Japanese Women
Effect of Low Dose Vitamin K2 (MK-4) Supplementation on Bio-Indices in Postmenopausal Japanese Women
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DOI：
10.3177/jnsv.55.15
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发表时间：
2009-02-01
影响因子：
1.6
通讯作者：
Ishimi, Yoshiko
中科院分区：
文献类型：
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作者：
Koitaya, Noriko;Ezaki, Junko;Ishimi, Yoshiko
据报道，用药理剂量（45 mg/d）的甲基萘醌-4（MK-4）治疗可预防绝经后妇女的骨丢失。然而，目前尚不清楚补充低剂量MK-4是否对健康女性的骨代谢有有益影响。本研究的目的是检查补充1.5 mg/d MK-4 4 4周对健康绝经后日本妇女骨和脂质代谢的影响。本研究是一项随机、双盲、安慰剂对照试验。年龄在53- 65岁的参与者被随机分为2组，分别补充MK-4 1.5 mg/d或安慰剂4 wk（每组n=20）。MK-4摄入量对血清骨钙素（OC）浓度的影响最显着。MK-4组血清低羧化OC（ucOC）浓度降低，而表明OC γ-羧化程度的γ-羧化OC（GlaOC）和GlaOC/GlaOC+ucOC比值在2和4 wk时与基线相比显著增加。MK-4组2 wk时血清ucOC和GlaOC浓度与安慰剂组相比差异有统计学意义。这些结果表明，补充1.5 mg/d MK-4可加速OC γ-羧化程度。两组干预期间的血脂浓度及其他指标均无差异。因此，额外摄入MK-4可能有利于维持绝经后日本妇女的骨骼健康。
It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this study is to examine the effects of the supplementation of 1.5 mg/d MK-4 for 4 wk on bone and lipid metabolism in healthy postmenopausal Japanese women. The Study was performed as a randomized double blind placebo-con trolled trial. The participants aged 53-65y were randomly assigned to 2 groups and supplemented with 1.5 mg/d of MK-4 or a placebo for 4 wk (n=20 for each group). The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. Serum undercarboxylated OC (ucOC) concentration decreased, and the gamma-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC gamma-carboxylation increased significantly at 2 and 4 wk compared with that at baseline in the MK-4 group. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2 wk. These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.