Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress
Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress
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DOI：
10.1017/s0033291712001390
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发表时间：
2013-03-01
影响因子：
6.9
通讯作者：
Kilts, C. D.
中科院分区：
文献类型：
--
作者：
Cisler, J. M.;James, G. A.;Kilts, C. D.
背景早期生活压力（ELS）是抑郁症的重要危险因素。ELS暴露对神经网络组织的影响尚未与抑郁症的影响区分开来。此外，许多暴露于ELS的个体不会发展为抑郁症，但区分弹性与易受ELS致抑郁效应影响的网络组织模式尚不清楚。年龄在18-44岁的女性，有ELS病史但无抑郁病史（n=7），有ELS病史且目前或过去有抑郁症（n=19），或既无ELS病史也无抑郁症（n=12），接受静息态3-T功能磁共振成像（fMRI）扫描。用图形分析法描述了一个由21个节点组成的情绪调节脑网络，并进行了组间比较。网络拓扑结构的组差异涉及右腹外侧前额叶皮层（vlPFC）的全局连接性和中枢样特性下降，背侧前扣带皮层（dACC）的局部网络连接性下降。在易感个体中观察到左杏仁核的局部连接性降低和枢纽样特性增加，dACC的枢纽样特性降低和左vlPFC的局部连接性降低。回归分析表明，ELS的严重程度（自我报告测量）与左背外侧PFC（dlPFC）的整体连通性和中枢样质量呈负相关。这些初步结果表明，功能性神经连接模式ELS曝光和弹性与ELS曝光的抑郁症的影响的易感性。
Background. Early life stress (ELS) is a significant risk factor for depression. The effects of ELS exposure on neural network organization have not been differentiated from the effect of depression. Furthermore, many individuals exposed to ELS do not develop depression, yet the network organization patterns differentiating resiliency versus susceptibility to the depressogenic effects of ELS are not clear.Method. Women aged 18-44 years with either a history of ELS and no history of depression (n=7), a history of ELS and current or past depression (n=19), or a history of neither ELS nor depression (n=12) underwent a resting-state 3-T functional magnetic resonance imaging (fMRI) scan. An emotion regulation brain network consisting of 21 nodes was described using graph analyses and compared between groups.Results. Group differences in network topology involved decreased global connectivity and hub-like properties for the right ventrolateral prefrontal cortex (vlPFC) and decreased local network connectivity for the dorsal anterior cingulate cortex (dACC) among resilient individuals. Decreased local connectivity and increased hub-like properties of the left amygdala, decreased hub-like properties of the dACC and decreased local connectivity of the left vlPFC were observed among susceptible individuals. Regression analyses suggested that the severity of ELS (measured by self-report) correlated negatively with global connectivity and hub-like qualities for the left dorsolateral PFC (dlPFC).Conclusions. These preliminary results suggest functional neural connectivity patterns specific to ELS exposure and resiliency versus susceptibility to the depressogenic effects of ELS exposure.