THREE-DIMENSIONAL ANALYSIS OF SUBMACULAR PERFORATING SCLERAL VESSELS BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
THREE-DIMENSIONAL ANALYSIS OF SUBMACULAR PERFORATING SCLERAL VESSELS BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1097/iae.0000000000001686
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发表时间：
2018-06-01
影响因子：
3.3
通讯作者：
Hasler, Pascal W.
中科院分区：
文献类型：
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作者：
Rothenbuehler, Simon P.;Maloca, Peter;Hasler, Pascal W.
目的：目的：应用增强型深度成像光谱域光学相干断层扫描（EDI-SDOCT）技术分析黄斑下巩膜穿通血管（PSV）。采集中央EDI-SDOCT扫描（3 x 4.5 x 1.9 mm，13.5 mm（2）扫描区域），并通过去噪、手动巩膜分割和PSV进行后处理，由5名分级者进行调查。平均屈光不正为-0.44 +/- 0.8屈光度。平均眼轴长度为23.08 ± 0.63 mm，分级一致性良好。黄斑下PSV的平均数量为0.33 +/- 0.2/mm（2）（范围为0 - 9/眼）。子场分析显示，中心直径为1 mm和3 mm的血管分别为0.2 +/- 0.5（范围0-2）和2.1 +/- 1.8（范围0-7）。象限分析显示，上级、低级、鼻部和颞部象限的血管分别为0.7 +/-0.9、0.5 +/- 0.9、0.3 +/- 0.6和0.4 +/- 0.6。PSV的总数目无显著性侧别差异（中位数差异0.5，可信区间-3.0 ~3.0，P = 0.94），也无眼轴长度的影响（P = 0.16）。该方法允许在后极处的外部视网膜灌注的关键组分的体内成像。
Purpose: To analyze submacular perforating scleral vessels (PSVs) using enhanced depth imaging spectral domain optical coherence tomography (EDI-SDOCT).Methods: Twenty-two eyes of 11 healthy women were included in this retrospective study. Central EDI-SDOCT scans (3 x 4.5 x 1.9 mm, 13.5 mm(2) scan area) were acquired and postprocessed by denoising, manual sclera segmentation, and PSV investigated by five graders.Results: Mean age was 22.4 +/- 6.2 years. Mean refractive error was -0.44 +/- 0.8 diopters. Mean axial length was 23.08 +/- 0.63 mm. The coefficient of agreement for grading was good. Mean number of submacular PSVs was 0.33 +/- 0.2 per mm(2) (range from 0 to 9 per eye). Subfield analysis showed 0.2 +/- 0.5 (range 0-2) and 2.1 +/- 1.8 (range 0-7) vessels, respectively, for central 1-mm diameter and 3-mm diameter. Quadrant analysis showed 0.7 +/- 0.9, 0.5 +/- 0.9, 0.3 +/- 0.6, and 0.4 +/- 0.6 vessels, respectively for superior, inferior, nasal, and temporal quadrants. Total number of PSV showed no significant side difference (median difference 0.5, confidence interval -3.0 to 3.0, P = 0.94) or an influence of axial length (P = 0.16).Conclusion: This is the first description of three-dimensional EDI-SDOCT visualization of submacular PSV in healthy eyes. This method allows for in vivo imaging of a critical component of outer retinal perfusion at the posterior pole.