Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila
Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila
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DOI：
10.1523/jneurosci.23-33-10495.2003
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发表时间：
2003-11-19
影响因子：
5.3
通讯作者：
Heisenberg, M
中科院分区：
文献类型：
--
作者：
Schwaerzel, M;Monastirioti, M;Heisenberg, M
儿茶酚胺在行为调节中发挥着重要作用。在这里，我们研究了黑腹果蝇中多巴胺和章鱼胺（推测是去甲肾上腺素的节肢动物同源物）在食欲和厌恶嗅觉记忆形成过程中的作用。我们发现，对于两种类型记忆的形成，cAMP 信号传导在蘑菇体内在神经元的同一亚群中是必要且充分的。另一方面，记忆形成可以通过对不同儿茶酚胺的需求来区分，多巴胺用于厌恶性调节，章多巴胺用于食欲调节。我们的结果表明，在联想条件作用中，不同的记忆是在不同的情况下由相同的气味形成的，并且它们通过特定的调节途径与各自的动机系统联系起来。
The catecholamines play a major role in the regulation of behavior. Here we investigate, in the fly Drosophila melanogaster, the role of dopamine and octopamine (the presumed arthropod homolog of norepinephrine) during the formation of appetitive and aversive olfactory memories. We find that for the formation of both types of memories, cAMP signaling is necessary and sufficient within the same subpopulation of mushroom-body intrinsic neurons. On the other hand, memory formation can be distinguished by the requirement for different catecholamines, dopamine for aversive and octopamine for appetitive conditioning. Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways.