THE FREQUENCY OF LONG-TERM REMISSION IN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA TREATED WITH CONVENTIONAL MAINTENANCE CHEMOTHERAPY - A STUDY OF 760 PATIENTS WITH A MINIMAL FOLLOW-UP TIME OF 6 YEARS
THE FREQUENCY OF LONG-TERM REMISSION IN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA TREATED WITH CONVENTIONAL MAINTENANCE CHEMOTHERAPY - A STUDY OF 760 PATIENTS WITH A MINIMAL FOLLOW-UP TIME OF 6 YEARS
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DOI：
10.1111/j.1365-2141.1989.tb04253.x
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发表时间：
1989-02-01
影响因子：
6.5
通讯作者：
HOLLAND, JF
中科院分区：
文献类型：
--
作者：
PREISLER, HD;ANDERSON, K;HOLLAND, JF
对急性髓系白血病患者给予常规维持化疗的缓解时间进行了评估。本文回顾了1974-1979年间760例进入缓解期的患者的病历。中位缓解期为1.1年，16%的患者在8年后仍处于缓解期。复发曲线是双相的，在缓解的前21年半期间复发率高，此后复发率低得多。白血病复发是通过8年的缓解观察到的。表明免于白血病复发风险的平台期尚不明显，但在缓解第八年后可能存在。
Remission duration associated with the administration of conventional maintenance chemotherapy to patients with acute myelogenous leukaemia was evaluated. The records of 760 patients who entered remission between 1974 and 1979 were reviewed. The median duration of remission was 1.1 years with 16% of patients remaining in remission at 8 years. The relapse curve was biphasic with a high rate of relapse during the first 21/2 years of remission followed by a much lower relapse rate thereafter. Leukaemic relapse were noted through 8 years of remission. A plateau phase indicating freedom from the risk of leukaemic recurrences not clearly apparent yet but may exist after the eighth year of remission.