Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research.
Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research.
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天然药物对 microRNA 的调节：化学预防和化疗研究的新兴领域。
DOI：
10.1007/s11095-010-0105-y
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发表时间：
2010-06
影响因子：
3.7
通讯作者：
Sarkar, Fazlul H.
中科院分区：
文献类型：
--
作者：
Li, Yiwei;Kong, Dejuan;Wang, Zhiwei;Sarkar, Fazlul H.
近年来，microRNA在癌症研究中受到越来越多的关注。这些小的非编码 RNA 可以通过与靶 mRNA 的 3' 非翻译区结合来抑制靶基因表达，从而导致 mRNA 降解或翻译抑制。 miRNA 在许多正常的生物过程中发挥着重要作用；然而，研究也表明异常的miRNA表达与癌症的发生和进展相关。 miRNA 可能具有致癌或肿瘤抑制活性。此外，一些miRNA可以调节癌症干细胞的形成和通常具有耐药性的癌细胞的上皮-间质转化表型。此外，miRNA可以用作诊断和预后的生物标志物，因此miRNA正在成为癌症治疗的新兴靶点。最近的研究表明，姜黄素、异黄酮、吲哚-3-甲醇、3,3'-二吲哚甲烷、(−)-表没食子儿茶素-3-没食子酸酯、白藜芦醇等天然药物可以改变miRNA表达谱，从而抑制癌细胞生长、诱导细胞凋亡、逆转上皮间质转化或增强传统癌症治疗的疗效。这些新出现的结果清楚地表明，天然药物对 miRNA 的特异性靶向可以通过杀死耐药细胞来彻底根除肿瘤，从而改善被诊断患有恶性肿瘤的患者的生存结果。
In recent years, microRNAs have received greater attention in cancer research. These small, non-coding RNAs could inhibit target gene expression by binding to the 3′ untranslated region of target mRNA, resulting in either mRNA degradation or inhibition of translation. miRNAs play important roles in many normal biological processes; however, studies have also shown that aberrant miRNA expression is correlated with the development and progression of cancers. The miRNAs could have oncogenic or tumor suppressor activities. Moreover, some miRNAs could regulate formation of cancer stem cells and epithelial-mesenchymal transition phenotype of cancer cells which are typically drug resistant. Furthermore, miRNAs could be used as biomarkers for diagnosis and prognosis, and thus miRNAs are becoming emerging targets for cancer therapy. Recent studies have shown that natural agents including curcumin, isoflavone, indole-3-carbinol, 3,3′-diindolylmethane, (−)-epigallocatechin-3-gallate, resveratrol, etc. could alter miRNA expression profiles, leading to the inhibition of cancer cell growth, induction of apoptosis, reversal of epithelial-mesenchymal transition, or enhancement of efficacy of conventional cancer therapeutics. These emerging results clearly suggest that specific targeting of miRNAs by natural agents could open newer avenues for complete eradication of tumors by killing the drug-resistant cells to improve survival outcome in patients diagnosed with malignancies.
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DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
8.8
作者：
Diosdado B;van de Wiel MA;Terhaar Sive Droste JS;Mongera S;Postma C;Meijerink WJ;Carvalho B;Meijer GA
通讯作者：
Meijer GA
影响因子：
5.8
作者：
Anand, Preetha;Nair, Hareesh B.;Sung, Bokyung;Kunnumakkara, Ajaikumar B.;Yadav, Vivek R.;Tekmal, Rajeshwar R.;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
64.8
作者：
Denli, AM;Tops, BBJ;Hannon, GJ
通讯作者：
Hannon, GJ
影响因子：
8
作者：
Chen, X.;Guo, X.;Zhang, C-Y
通讯作者：
Zhang, C-Y