The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
复制标题
DOI：
10.1101/gad.215152.113
复制
发表时间：
2013-05-01
影响因子：
10.5
通讯作者：
Hadjantonakis, Anna-Katerina
中科院分区：
文献类型：
--
作者：
Nowotschin, Sonja;Costello, Ita;Hadjantonakis, Anna-Katerina
胚胎和胚胎外组织之间的相互诱导相互作用建立了早期小鼠胚胎的前后轴。胚胎第5.5天，前内脏内胚层（AVE）信号中心出现在胚胎远端，并向胚胎前侧移位。AVE的诱导和迁移过程尚不清楚。在这里，我们证明了T-box基因eomesdermin （Eomes）在AVE募集中起着至关重要的作用，部分是通过直接激活同源盒转录因子Lhx1。因此，Eomes在内脏内胚层（VE）中的功能启动了一个控制AP身份的指导性转录程序。
Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1. Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity.