Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly.
Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly.
复制标题
空巢相关的心理困扰与老年人脑白质病变进展和认知障碍有关
DOI：
10.1038/srep43816
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发表时间：
2017-03-03
影响因子：
4.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Duan D;Dong Y;Zhang H;Zhao Y;Diao Y;Cui Y;Wang J;Chai Q;Liu Z
本研究评估了219名60岁以上老年受试者中空巢相关心理困扰与白色病变（WML）和认知障碍进展之间的关系。采用加州大学洛杉矶分校孤独量表（UCLA-LS）和老年抑郁量表（GDS）简表评估心理困扰。使用MMSE和莫卡评估认知功能。使用磁共振成像评估白色高信号（WMH）。随访5.2年后，空巢老人MMSE和莫卡评分的降低以及脑室周围（P）WMH、深部（D）WMH和总WMH体积的增加均大于非空巢老人（P < 0.05）。独居空巢老人MMSE和莫卡评分降低、PWMH和总WMH体积增加均大于与配偶同住空巢老人（P < 0.05）。UCLA-LS和GDS评分与MMSE和莫卡评分降低以及PWMH、DWMH和总WMH体积增加显著独立相关。结果表明，空巢相关的心理困扰与老年人的WML和认知障碍的进展。
This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Loneliness Scale (UCLA-LS) and Geriatric Depression Scale (GDS) Short-Form. Cognitive function was evaluated using the MMSE and MoCA. White matter hyperintensities (WMH) were assessed using magnetic resonance imaging. After 5.2-year follow-up, the reductions in MMSE and MoCA scores and the increases in periventricular (P)WMH, deep (D)WMH, and total WMH volumes in the empty-nest elderly were greater than those in the non-empty-nest elderly (P < 0.05). The reduced MMSE and MoCA scores and increased volumes of PWMH and total WMH in the empty-nest elderly living alone were greater than those in the empty-nest elderly living with a spouse (P < 0.05). UCLA-LS and GDS scores were significantly and independently associated with reduced MMSE and MoCA scores and the increased volumes of PWMH, DWMH, and total WMH. The results indicate that empty-nest-related psychological distress is associated with progression of WMLs and cognitive impairment in the elderly.